2009 Fiscal Year Final Research Report
Application of hydrogels for adhesion prevention after thoracotomy
| Project/Area Number |
19591645
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Keio University |
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Principal Investigator |
IZUMI Yotaro Keio University, 医学部, 助教 (90245506)
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| Co-Investigator(Kenkyū-buntansha) |
ASAKURA Keisuke 慶應義塾大学, 医学部, 研究員(非常勤) (90383786)
KAWAMURA Masafumi 慶應義塾大学, 医学部, 准教授 (70169770)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 癒着 / 吸水性ハイドロゲル / ポリグルタミン酸架橋体 |
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| Research Abstract |
Cross-linked poly (gamma-glutamic acid) (PGAXL) is a biodegradable polymer capable of forming a hydrogel. In the present study, using a mouse model of thoracotomy, we investigated whether local application of PGAXL could attenuate adhesion formation at the thoracotomy site. We found that local application of PGAXL attenuated adhesion formation at the site of thoracotomy between the lung and the parietal pleura as well as between the chest wall and the chest muscles..
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