Utility of diffusion tensor imaging in the diffuse axonal injury for detecting white matter lesions and predicting long-term cognitive function

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591674
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kobe University
• Principal Investigator: HOSODA Kohkichi Kobe University, 医学研究科, 准教授 (90403261)
• Co-Investigator(Kenkyū-buntansha): KOHMURA Eiji 神戸大学, 医学研究科, 教授 (30225388) ; FUJII Masahiko 神戸大学, 医学部附属病院, 准教授 (00228959)
• Project Period (FY): 2007 – 2009
• Keywords: MRI / 拡散テンソル画像 / 頭部外傷 / び漫性軸索損傷 / arterial spin labeling / 脳血流

Research Abstract

《DTI study》Twenty adult patients with mild to moderate traumatic brain injury (TBI) underwent diffusion tensor imaging. Fractional anisotropy of TBI was significantly lower than control in genu, stem and splenium of corpus callosum. Furthermore, reduction of fractional anisotropy in splenium and frontal white matter in acute stage was significantly associated with long-term cognitive dysfunction of mild to moderate traumatic brain injury.《perfusion MRI study》Arterial spin labeling (ASL) is an emerging technique for noninvasive measurement of cerebral perfusion. Twenty patients with carotid stenosis underwent cerebral blood flow (CBF) and vasoreactivity quantification by ASL to determine the utility of ASL in patients with cerebrovascular diseases. CBF and vasoreactivity by ASL agreed with SPECT. Furthermore, ASL could detect pathologic states, equivalent to SPECT. However, ASL tended to overestimate CBF values especially in high-perfusion regions. As a conclusion, ASL perfusion MR imaging is clinically applicable.

Research Products

• [Journal Article] Diffusion tensor imaging in acute stage is useful to detect the white matter lesions and to predict the long-term cognitive prognosis of mild to moderate traumatic brain injury in adults. (2011)
  • Author(s): Matsushita M, Hosoda K, Naitoh Y, Yamashita H, Kohmura E
  • Journal Title: J Neurosurg in press
• [Journal Article] Clinical application of Arterial Spin Labeling MRI in patients with carotid stenosis -quantitative comparative study with SPECT- (2011)
  • Author(s): Uchihashi Y, Hosoda K, Zimine I, Fujita A, Fujii M, Sugimura K, Kohmura E
  • Journal Title: AJNR Am J Neuroradiol in press
• [Presentation] Diffusion tensor imaging in the acute stage of mild to moderate head injury is useful to detect the white matter lesions and to predict the long-term prognosis. (2010)
  • Author(s): 細田弘吉, 松下誠, 甲村英二
  • Organizer: The 2nd International Congress of Asia Oceania Neurotrauma Society
  • Place of Presentation: Tokyo
  • Year and Date: 20100000
• [Presentation] Clinical application of Arterial Spin Labeling MRI in patients with carotid stenosis -quantitative comparative study with SPECT-. (2010)
  • Author(s): Uchihashi Y, Hosoda K, Zimine I, Yamamoto D, Aoyama N, Fujii, M, Kohmura E
  • Organizer: The 60th Congress of Neurological Surgeons
  • Place of Presentation: San Frabcisoco
  • Year and Date: 20100000
• [Presentation] ASL(QUASAR)法を用いた無侵襲脳灌流画像撮像法の臨床応用 (2010)
  • Author(s): 内橋義人, 細田弘吉, Ivan Zimine, 藤井康彦, 青山信和, 甲村英二
  • Organizer: 第39回脳卒中の外科学会総会シンポジウム:脳卒中の日常臨床における脳循環代謝画像:有用性と限界
  • Place of Presentation: 盛岡
  • Year and Date: 20100000
• [Presentation] Comparison of CBF Measurement by ASL and SPECT in Patients with Carotid Stenosis. (2009)
  • Author(s): Uchihashi Y, Hosoda K, Zimine I, Fujita A, Inoue S, Aihara H, Kawamitsu H, Aoyama N, Aoki H, Fujii M, Kohmura E
  • Organizer: International Society for magnetic resonance in medicine (ISMRM) 17th Scientific Meeting & Exhibition
  • Place of Presentation: Honolulu
  • Year and Date: 20090000
• [Presentation] Arterial Spin Labeling (ASL)-MRIによる脳灌流画像の臨床応用-SPECTとの比較- (2009)
  • Author(s): 内橋義人, 細田弘吉, 藤田敦史, イワン・ジミー, 藤田敦史, 井上悟志, 青山信和, 神澤匡数, 川光秀昭, 青木一, 藤井正彦, 甲村英二
  • Organizer: 第38回日本神経放射線学会シンポジウムIII機能画像の有用性と限界
  • Place of Presentation: 水戸
  • Year and Date: 20090000
• [Presentation] ASL-MRIによる新しい脳灌流画像の臨床応用ーSPECTとの比較ー (2009)
  • Author(s): 内橋義人, 細田弘吉, 藤田敦史, イワン・ジミー, 青山信和, 川光秀昭, 藤井正彦, 井上悟志, 甲村英二
  • Organizer: 第38回脳卒中の外科学会総会シンポジウム:脳卒中画像診断の最先端
  • Place of Presentation: 松江
  • Year and Date: 20090000
• [Presentation] Detection of neurological (neuropathological) changes in white matter and evaluation of prognosis by diffusion tensor images. (2008)
  • Author(s): 松下誠, 原淑恵, 山下晴央, 細田弘吉, 甲村英二
  • Organizer: The 26th Annual National Neurotrauma Symposium
  • Place of Presentation: Orlando
  • Year and Date: 20080000
• [Presentation] 拡散テンソル画像による頭部外傷における白質病変検出の試みと予後との関連 (2008)
  • Author(s): 松下誠, 山本大輔, 太田耕平, 原淑恵, 山下晴央, 細田弘吉, 甲村英二
  • Organizer: 第31回日本神経外傷学会シンポジウム3:高次機能障害-病態の解明-
  • Place of Presentation: 大阪
  • Year and Date: 20080000
• [Remarks] ホームページ等