Gene expression profiles in endometrial carcinoma

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591939
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagoya City University
• Principal Investigator: NISHIKAWA Hiroshi Nagoya City University, 大学院・医学研究科, 助教 (00347410)
• Project Period (FY): 2007 – 2009
• Keywords: 婦人科腫瘍学 / 子宮体癌 / 分子診断 / プロファイル

Research Abstract

The gene expression profiles of human endometrial carcinoma were analysed by serial of gene expression (SAGE) which allows quantitative and simultaneous analysis of a large number of transcripts. More than 22000 transcripts deriverd from a normal endometrial tissue and endometrial carcinoma tissue were analysed. While extensive similarity was noted between the expression profiles of the normal endometrial tissue and endometrial carcinoma tissue, many transcripts, such as B-factor properdin, uridine phosphorylase, and cyclin G1 interacting protein, were expressed at extremely different levels in differentiated and undifferentiated carcinoma. These data provide new information that might be used to identify genes useful for the diagnosis and treatment of endometrial carcinoma.