Molecular genetic analysis of recurrence of endogenous uveitis

2010 Fiscal Year Final Research Report

• Project/Area Number: 19592003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: KITAICHI Nobuyoshi Hokkaido University, 大学院・医学研究科, 客員准教授 (40431366)
• Co-Investigator(Kenkyū-buntansha): OHNO Shigeaki 北海道大学, 大学院・医学研究科, 特任教授 (50002382) ; NAMBA Kenichi 北海道大学, 北海道大学病院, 講師 (70333599) ; YOSHIDA Kazuhiko 北海道大学, 北海道大学病院, 講師 (90281807) ; OHGAMI Kazuhiro 北海道大学, 大学院・医学研究科, 客員研究員 (80443977)
• Project Period (FY): 2007 – 2010
• Keywords: 遺伝子 / 免疫学 / 臨床遺伝子 / 分子遺伝学 / 臨床 / ベーチェット病 / Vogt-小柳-原田病

Research Abstract

Disease susceptibility genes and prognostic factors of endogenous uveitis were examined in this project. First, descriptive questionnaires were collected from 25 eye centers in 14 countries. Behcet disease is still a common cause of blindness in Asia. It was less common in children than in adults in East/South Asian countries. Second, DNA samples were collected to analyze molecular genetic factors associated with clinical characteristics and prognostic factors of uveitic diseases. Some gene polymorphisms were associated with the diseases : Behcet disease, sarcoidosis, Vogt-Koyanagi-Harada disease, and vitiligo vulgaris. Polymorphisms expected to the recurrence of uveitis was analyzed in Behcet disease compared with Vogt-Koyanagi-Harada disease.

Research Products

• [Journal Article] Genome-wide association studies identify IL23R/IL12RB2 and IL10 as Behcet's disease susceptibility loci. (2010)
  • Author(s): Mizuki N, Meguro A, Ota M, Ohno S, Kitaichi N, Namba K
  • Journal Title: Nat Genet 42 Pages: 703-706
  • Peer Reviewed
• [Journal Article] Association of TLR4 polymorphism with Behcet disease in Korean populatin. (2009)
  • Author(s): Horie Y, Meguro A, Ota M, Kitaichi N, Namba K, Ohno S
  • Journal Title: Rheumatology 48 Pages: 638-642
  • Peer Reviewed
• [Journal Article] Low prevalence of juvenile onset Behcet's disease with uveitis in East/South Asian people. (2009)
  • Author(s): Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S
  • Journal Title: Br J Ophthalmol 93 Pages: 1428-1430
  • Peer Reviewed
• [Journal Article] The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (α-MSH) therapy. (2008)
  • Author(s): Taylor AW, Kitaichi N
  • Journal Title: Brain Behav Immun 22 Pages: 639-646
  • Peer Reviewed
• [Presentation] Clinical features of uvetis with Behcet disease and the new therapeutic approach in the animal model. (2010)
  • Author(s): Kitaichi N
  • Organizer: International Uveitis Study Group (IUSG) Meeting
  • Place of Presentation: Berlin, Germany(招待審査講演)
  • Year and Date: 2010-06-06
• [Presentation] Low prevalence of juvenile-onset Behcet disease with uveitis in East/South Asian people. (2009)
  • Author(s): Kitaichi N
  • Organizer: 2^<nd> International Uveitis & 3^<rd> Asia-Pacific Intraocular Inflammation Symposium
  • Place of Presentation: Chongqing, China(受賞記念招待講演)
  • Year and Date: 2009-11-06
• [Presentation] Infectious uveitis and intraocular inflammation. (2009)
  • Author(s): Kitaichi N
  • Organizer: 24^<th> Congress of Asia-Pacific Academy of Ophthalmology (APAO) and American Academy of Ophthalmology (AAO) Joint Meeting
  • Place of Presentation: Bali, Indonesia(招待講演)
  • Year and Date: 2009-05-19
• [Book] 眼疾患の謎(Behcet病はなぜシルクロード沿いの諸民族に多発するのか) (2010)
  • Author(s): 大野重昭、北市伸義
  • Total Pages: 137-139
  • Publisher: 文光堂
• [Book] Int Ophthalmol Clin 48, Behcet disease in children. (2008)
  • Author(s): 北市伸義, 大野重昭
  • Total Pages: 87-91
  • Publisher: Lippincott Williams & Wilkins Co (USA).
• [Book] 眼科プラクティス23眼科薬物治療A to Z.Vogt-小柳-原田病・交感性眼炎 (2008)
  • Author(s): 北市伸義
  • Total Pages: 136-138
  • Publisher: 文光堂
• [Remarks] BioMedLibトップ10論文賞(アメリカ・バージニア州、2011年3月)
• [Remarks] アジア太平洋内眼炎症学会若手研究者賞(開催地:中国・重慶、事務局:シンガポール、2009年11月)
• [Remarks] アメリカ視覚眼科学研究協会(ARVO)アルコン研究賞(開催地:アメリカ・フロリダ州、事務局:アメリカ・メリーランド州、2009年5月)