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2008 Fiscal Year Final Research Report

Study for mechanism of orofacial neuropathic pain

Research Project

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Project/Area Number 19592108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

TAKEMURA Motohide  Osaka University, 大学院・歯学研究科, 准教授 (70192169)

Co-Investigator(Kenkyū-buntansha) YONEHARA Norifumi  奥羽大学, 薬学部, 教授 (70124534)
KOBAYASHI Masayuki  日本大学, 大学院・歯学研究科, 准教授 (00300830)
SUGIYO Shinichi  大阪大学, 大学院・歯学研究科, 助教 (90397688)
Project Period (FY) 2007 – 2008
Keywords神経因性疼痛
Research Abstract

神経損傷ラットの情報伝達機構が大きく変化することが、神経因性疼痛発現の基礎にあることが明らかになった。ぺプチド性C線維を介したシグナリングが侵害刺激をよりシャープに上位中枢に送るが、非ぺプチド性C線維のシグナリングがそのぺプチド性C線維を抑制するといった制御に関わっている可能性を示すデーターを得た

  • Research Products

    (13 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Functional organization of the rodent parabrachial nucleus2009

    • Author(s)
      Yamamoto T, Takemura M, Inui T, Torii K, Maeda N, Ohmoto Makoto, Matsumoto I,Abe K
    • Journal Title

      Annals of New York Acad Science (in press)

    • Peer Reviewed
  • [Journal Article] Effects of systemic bicuculline or morphine on formalin-evoked pain-relatedbehaviour and c-Fos expression intrigeminal nuclei after formalininjection into the lip or tongue in rats2009

    • Author(s)
      Sugiyo S, Uehashi D, Satoh F, Abe T, Yonehara N, Kobayashi M, Takemura M
    • Journal Title

      Exp Brain Res 196

      Pages: 229-237

    • Peer Reviewed
  • [Journal Article] Luminal hydrogen sulfide plays a pronociceptiverole in mouse colon2009

    • Author(s)
      Matsunami M, Tarui T, Mitani K, Nagasawa K, Fukushima O, Okubo K, YoshidaS, Takemura M, Kawabata A
    • Journal Title

      Gut 58

      Pages: 751-761

    • Peer Reviewed
  • [Journal Article] Capsaicin-induced glutamate release is implicated in nociceptive processingthrough activation of ionotropicglutamate receptors and group Imetabotropic glutamate receptor inprimary afferent fibers2009

    • Author(s)
      Jin Y-H, Yamaki F, Takemura M, Koike Yuichi, Furuyama A, Yonehara N
    • Journal Title

      J Pharmacol Sci 109

      Pages: 233-241

    • Peer Reviewed
  • [Presentation] (2008) Intra cisterna magna and rostral ventromedial medullainjection of anti-serotonintransporter-saporin bidirectionallychanged formalin-induced pain relatedbehaviour and c-Fos expression in themedullary dorsal horn in rats2008

    • Author(s)
      Sugiyo S., Uehashi D., Masawaki A., Ohyamaguchi A., Abe T., Yonehara N.,Takemura M.
    • Organizer
      Annual meetings of Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-11-17
  • [Presentation] Nociceptive behavioral responses c-Fosand pERK expression in neonatallycapsaicin-pretreated rat2008

    • Author(s)
      Uehashi D., Sugiyo S., Masawaki A., Ohyamaguchi A., Abe T., Takemura M.
    • Organizer
      meetings of Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-11-17
  • [Presentation] Neurokinin-1-receptor bearing neurons inthe trigeminal caudal nucleus are crucialfor intensity-dependent bidirectionalsensory processing through GABAAreceptors.2008

    • Author(s)
      Abe T., Takemura M., Sugiyo S., Ohyamaguchi A., Masawaki A., HasegawaM.,Honda K., Urade M.
    • Organizer
      Federation of European Neurosciences Societies Forum
    • Place of Presentation
      Geneva
    • Year and Date
      2008-07-13
  • [Presentation] Elimination of IB4-positive trigeminalganglion neurons decreased nociceptiveresponses of the formalin-inducedpain-related behavior at first phase inthe upper lip and c-Fos expression in thetrigeminal caudal nucleus in rats2008

    • Author(s)
      Ohyamaguchi A., Sugiyo S., Abe T., Masawaki A., Niwa H., Takemura M.
    • Organizer
      Federation of European Neurosciences Societies Forum
    • Place of Presentation
      Geneva
    • Year and Date
      2008-07-13
  • [Presentation] NK-1 receptor-bearing neurons are essentialfor systemic bicuculline- inducedantinociception in formalin test2008

    • Author(s)
      Masawaki A., Sugiyo S., Ohyamaguchi A., Abe T., Niwa H., Takemura M. (2008) NK-1receptor-bearing neurons are essentialfor systemic bicuculline- inducedantinociception in formalin test
    • Organizer
      Federation of European Neurosciences Societies Forum
    • Place of Presentation
      Geneva
    • Year and Date
      2008-07-13
  • [Presentation] Effects of systemic bicuculline on the formalin-induced nociceptiveresponse in the lip and c-Fos expressionin the SP-Saporin-treated rats2007

    • Author(s)
      A Masawaki, S Sugiyo, T Shimoda, Y Sakai, A Ohyamaguchi, D Uehashi, MMoritani, A Yoshida, H Niwa, M Takemura
    • Organizer
      37th annual meeting of the Society forNeuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      20071103-07
  • [Presentation] Intra cisterna magna injection of pertussistoxin enhanced mechanical nociceptiveresponses and noxiousstimulation-induced pERK expression in the trigeminal nucleus caudalis2007

    • Author(s)
      S Sugiyo, Y Sakai, T Shimoda, A Masawaki, A Ohyamaguchi, D Uehashi, MMoritani, M Takemura
    • Organizer
      37th annual meeting of the Society forNeuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      20071103-07
  • [Presentation] Changes in sensitivity of glutamate receptors atthe peripheral endings of the nociceptivefivers following nerve injury2007

    • Author(s)
      F Yamaki, A Furuyama, M Takemura, Yuichi Koike, N Yonehara
    • Organizer
      30th Annual Meeting of Japan NeuroscienceSociety
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2007-09-10
  • [Book] (2008)口腔顔面の痛みのトピックス : 生命歯科医学のカッティング・エッジ(米田俊之編)COEモノグラフ2008

    • Author(s)
      竹村元秀、杉生真一
    • Total Pages
      244-254
    • Publisher
      大阪大学出版会

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Published: 2010-06-10   Modified: 2016-04-21  

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