2009 Fiscal Year Final Research Report
Development of vector calcium phosphate cement with high solubility
| Project/Area Number |
19592245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAWANO Fumiaki The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (60195120)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00301317)
OHISH Mika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50263851)
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| Research Collaborator |
SEKINE Kazumitu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生体材料 / 硬組織代替材料 / 骨補填材 / 骨再生工学 / セラミックス |
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| Research Abstract |
The purpose of this study is to evaluate the strength and other properties of CPC containing Sr and carbonate, and to show its superiority to current CPC.
The DTS of set cements containing SrCO_3 were significantly lower than that of non-Sr-containing CPC. The solubility of set cements using 5%SrCO_3 was twice those of set cements without SrCO_3. From histological observations implanted for 1 week, inflammatory macrophages and osteoclast cells migrated into the cavity. Results implanted for 4 weeks showed a small amount of new bone was observed, which covered the cavity. These processes were observed earlier in the group using O%SrCO_3 than in the control group. We have developed Sr-containing CPC with high solubility, which showed several advantages as a bone replacing material.
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