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2009 Fiscal Year Final Research Report

Development of an oral appliance that induces mandibular protrusion only when sleep apnea occurs and that positive pressure is driven if the apnea disappears

Research Project

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Project/Area Number 19592292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

YOSHIDA Kazuya  Department of Clinical Research, National Hospital Organization Kyoto Medical Center, 臨床研究企画運営部, 研究員 (90263087)

Co-Investigator(Kenkyū-buntansha) CHIN Kazuo  京都大学, 医学研究科, 教授 (90197640)
Project Period (FY) 2007 – 2009
Keywords睡眠時無呼吸症候群 / 口腔内装置 / CPAP / 経鼻持続陽圧呼吸療法 / 下顎運動
Research Abstract

We tried to develop an oral appliance that induces mandibular protrusion only when sleep apnea occurs and that positive pressure is driven if the apnea disappears. We attempted to change a soft program of continuous positive airway pressure but during the study period did not make it. The research is necessary further investigation.
The somatosensory evoked magnetic field analysis of electrical stimulation of the tongue was found to be useful to get information about finding and developing a sense of tongue and sleep apnea syndrome.
Measuring cerebral blood flow using near-infrared spectroscopy in patients with sleep apnea syndrome, dysfunction of the frontal lobe was elucidated with the syndrome.

  • Research Products

    (39 results)

All 2010 2009 2008 2007 Other

All Journal Article (19 results) (of which Peer Reviewed: 17 results) Presentation (15 results) Book (4 results) Remarks (1 results)

  • [Journal Article] 脳磁図計測における歯科用金属に由来するアーチファクト2010

    • Author(s)
      前澤仁志, 松橋眞生, 吉田和也, 澤本伸克, 美馬達哉, 長峯隆, 別所和久, 福山秀直
    • Journal Title

      認知神経科学 11

      Pages: 258-267

    • Peer Reviewed
  • [Journal Article] Associations between obstructive sleep apnea, metabolic syndrome and sleep duration, as measured with an actigraph, in an urban male working population in Japan2010

    • Author(s)
      Chin K, Oga T, Takahashi K, Takegami M, Nakayama-Ashida Y, Wakamura T, Sumi K, Nakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H
    • Journal Title

      Sleep 33

      Pages: 89-95

    • Peer Reviewed
  • [Journal Article] 口腔内装置治療の有効性と限界および顎矯正手術の展開2009

    • Author(s)
      吉田和也
    • Journal Title

      最新医学睡眠時無呼吸症候群特集号 64

      Pages: 76-88

  • [Journal Article] Shortened dental arch and cerebral regional blood volume-an experimental study with optical topography-2009

    • Author(s)
      Miyamoto I, Yoshida K, Bessho K
    • Journal Title

      J Craniomandibular Practice 27

      Pages: 94-100

    • Peer Reviewed
  • [Journal Article] apnea with intermittent hypoxia on platelet aggregability2009

    • Author(s)
      T, Chin K, Tabuchi A, Sumi K, Takahashi K, Handa T, Takahashi K, Taniguchi R, Kondo H, Kawato M, Morimoto T, Mishima M, Kita T, Horiuchi H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis 16

      Pages: 862-869

    • Peer Reviewed
  • [Journal Article] Abnormal Swallowing reflex and Chronic Obstructive Pulmonary Disease Exacerbations2009

    • Author(s)
      Terada K, Muro S, Ohara T, Kudo M, Ogawa E, Hoshino Y, Hirai T, Niimi A, Chin K, Mishima M
    • Journal Title

      Chest 137

      Pages: 326-332

    • Peer Reviewed
  • [Journal Article] Importance of ventilator mode in long-term noninvasive positive pressure ventilation2009

    • Author(s)
      Tsuboi T, Oga T, Machida K, Chihara Y, Matsumoto H, Niimi A, Sumi K, Ohi M, Mishima M, Chin K
    • Journal Title

      Respir Med (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Body mass index in male patients with chronic obstructive pulmonary disease; correlation with low attenuation areas on CT2009

    • Author(s)
      Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M
    • Journal Title

      Thorax 64

      Pages: 20-25

    • Peer Reviewed
  • [Journal Article] Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on Item Response Theory2009

    • Author(s)
      Takegami M, Suzukamo Y, Wakita T, Noguchi H, Chin K, Kadotani H, Inoue Y, Oka Y, Nakamura T, Green J, Johns MW, Fukuhara S
    • Journal Title

      Sleep Medicine

      Pages: 556-565

    • Peer Reviewed
  • [Journal Article] Prophylactic respiratory management after liver resection with bilevel positive airway pressure ventilation: Report of three cases2009

    • Author(s)
      Narita M, Hatano E, Nagata H, Yanagida A, Asechi H, Takahashi K, Ikai I, Chin K
    • Journal Title

      Surgery Today 39

      Pages: 172-174

    • Peer Reviewed
  • [Journal Article] Modified Epitec System abutment for magnetic retention of orbital prostheses2008

    • Author(s)
      Yoshida K, Takagi A, Tsuboi Y, Bessho K
    • Journal Title

      Journal of Prosthodontics 17

      Pages: 219-222

    • Peer Reviewed
  • [Journal Article] Somatosensory evoked magnetic fields following the tongue stimulation using needle electrodes2008

    • Author(s)
      Maezawa H, Yoshida K, Nagamine T, Matsubayashi J, Enatsu R, Bessho K, Fukuyama H
    • Journal Title

      Neuroscience Research 62

      Pages: 131-139

    • Peer Reviewed
  • [Journal Article] Computed Tomography analysis of airway dimensions and lung density in patients with sarcoidosis2008

    • Author(s)
      Handa T, Nagai S, Hirai T, Chin K, Kubo T, Oga T, Niimi A, Matsumoto H, Ito Y, Takahashi K, Watanabe K, Izumi T, Mishima M
    • Journal Title

      Respiration 77

      Pages: 273-281

    • Peer Reviewed
  • [Journal Article] Relationship between pulmonary emphysema and osteoporpsis assessed by CT in patients with COPD2008

    • Author(s)
      Ohara T, Hirai T, Muro S, Haruna A, Terada K, Kinose D, Marumo S, Ogawa E, Hoshino Y, Niimi A, Chin K, Mishima M
    • Journal Title

      Chest 134

      Pages: 1244-1249

    • Peer Reviewed
  • [Journal Article] Acylated ghrelin level in patients with obstructive sleep apnoea before and after nasal CPAP treatment2008

    • Author(s)
      Takahashi K, Chin K, Akamizu T, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Tsuboi T, Fukuhara S, Kangawa K, Mishima M
    • Journal Title

      Respirology 13

      Pages: 810-816

    • Peer Reviewed
  • [Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure2008

    • Author(s)
      Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M
    • Journal Title

      Antioxidants, Redox Signaling 10

      Pages: 715-726

    • Peer Reviewed
  • [Journal Article] Sleep-disordered breathing in the usual lifestyle setting as detected with home monitoring in a Japanese male working population2008

    • Author(s)
      Nakayama-Ashida Y, Takegami M, Chin K, Sumi K, Nakamura T, Takahashi K, Wakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H
    • Journal Title

      Sleep 31

      Pages: 419-425

    • Peer Reviewed
  • [Journal Article] Kansai Community Acquired Pneumococcal Pneumonia Study Group. Molecular characteristics of serotype 3 Streptococcus pneumoniae isolates among community-acquired pneumonia patients in Japan2008

    • Author(s)
      Isozumi R, Ito Y, Ishida T, Hirai T, Ito I, Maniwa K, Hayashi M, Kagioka H, Hirabayashi M, Onaru K, Tomioka H, Tomii K, Gohma I, Osawa M, Imai S, Takakura S, Iinuma Y, Chin K, Ichiyama S, Mishima M
    • Journal Title

      J Infect Chemother 14

      Pages: 258-261

    • Peer Reviewed
  • [Journal Article] 睡眠時無呼吸症候群の治療と予後3. 口腔内装置2007

    • Author(s)
      吉田和也
    • Journal Title

      Mebio睡眠時無呼吸症候群特集号 24

      Pages: 124-138

  • [Presentation] 閉塞型睡眠時無呼吸症候群の治療と今後の展望2010

    • Author(s)
      吉田和也
    • Organizer
      京都府社会保険診療報酬支払基金歯科学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-02-23
  • [Presentation] Effect of oral appliance therapy on blood pressure and its neurophysiological mechanism. The 6th Congress of Asian Sleep Research Society2009

    • Author(s)
      Yoshida K
    • Organizer
      The 34th Annual Meeting of Japanese Society of Sleep Research and The 16th Annual Meeting of Japanese Society for Chronobiology Joint Congress
    • Place of Presentation
      Osaka
    • Year and Date
      20091025-20091027
  • [Presentation] 歯周病と口腔ケア2009

    • Author(s)
      吉田和也
    • Organizer
      京都医療センター
    • Place of Presentation
      京都
    • Year and Date
      2009-06-15
  • [Presentation] 口腔顎顔面領域の筋緊張異常に起因する疾患の診断と治療2009

    • Author(s)
      吉田和也
    • Organizer
      大阪歯科大学
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-28
  • [Presentation] Brain functions in sleep apnea syndrome assessed by near-infrared spectroscopy2008

    • Author(s)
      Yoshida K, Maezawa H, Suzuki K, Yamada M, Ohno J
    • Organizer
      86th General Session, Exhibition of the International Association for Dental Research
    • Place of Presentation
      Toronto
    • Year and Date
      20080702-20080705
  • [Presentation] ピン電極を用いた舌の電気刺激による体性感覚誘発脳磁場反応の解析2008

    • Author(s)
      前澤仁志, 吉田和也, 長峯隆, 松林潤, 江夏怜, 別所和久, 福山秀直
    • Organizer
      第156回京都歯科口腔外科集談会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-20
  • [Presentation] 下顎第三大臼歯抜歯時に生じた舌神経損傷にMicroneurosurgeryを行った1例-2008

    • Author(s)
      松本隆司, 東條格, 根来健二, 山田大介, 木賀紀文, 藤田茂之, 前澤仁志, 吉田和也
    • Organizer
      第156回京都歯科口腔外科集談会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-20
  • [Presentation] Somatosensory evoked magnetic fields in patients with tongue sensory disturbance2008

    • Author(s)
      Maezawa H, Yoshida K, Nagamine T, Yokoyama Y, Matsuhashi M, Fukuyama H, Bessho K
    • Organizer
      The 16th International Conference on Biomagnetism
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-08-26
  • [Presentation] 顎口腔領域の不随意運動の診断と治療2008

    • Author(s)
      吉田和也
    • Organizer
      第155回京都歯科口腔外科集談会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-19
  • [Presentation] 体性感覚誘発脳磁場を用いた舌感覚異常の客観的評価2008

    • Author(s)
      前澤仁志, 吉田和也, 長峯隆, 横山洋平, 松橋眞生, 福山秀直, 別所和久
    • Organizer
      第62回日本口腔科学会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-04-18
  • [Presentation] 歯周病と生活習慣病の関連2008

    • Author(s)
      吉田和也
    • Organizer
      榊原白鳳病院生活習慣病セミナー
    • Place of Presentation
      津
    • Year and Date
      2008-02-23
  • [Presentation] 睡眠時無呼吸症候群の歯科口腔外科的治療法2008

    • Author(s)
      吉田和也
    • Organizer
      松本歯科大学病院セミナー
    • Place of Presentation
      塩尻
    • Year and Date
      2008-01-23
  • [Presentation] 舌刺激体性感覚誘発脳磁場の解析2007

    • Author(s)
      前澤仁志, 吉田和也, 松林潤, 別所和久, 長峯隆, 福山秀直
    • Organizer
      第37回日本臨床神経生理学会
    • Place of Presentation
      栃木
    • Year and Date
      20071119-20071123
  • [Presentation] Somatosensory evoked magnetic fields following the tongue stimulation2007

    • Author(s)
      Maezawa H, Yoshida K, Matsubayashi J, Bessho K, Nagamine T, Fukuyama H
    • Organizer
      First Conference of International Society for the Advancement of Clinical Magnetoencephalography
    • Place of Presentation
      Sendai
    • Year and Date
      20070827-20070830
  • [Presentation] 睡眠時無呼吸症候群におけるスプリント治療の技工作業2007

    • Author(s)
      吉田和也
    • Organizer
      第153回京都歯科口腔外科集談会
    • Place of Presentation
      京都
    • Year and Date
      2007-07-21
  • [Book] Sleep apnea syndrome from clinical and neurophysiological aspects in the stomatognathic system2010

    • Author(s)
      Yoshida K
    • Publisher
      Nova Science Publishers
  • [Book] 睡眠に関する口腔衛生2009

    • Author(s)
      吉田和也
    • Total Pages
      644-648
    • Publisher
      朝倉書店
  • [Book] 口腔内装置(閉塞型に対して). 麻野井英次編, 睡眠時無呼吸症候群-循環器臨床に必要な知識2008

    • Author(s)
      吉田和也
    • Total Pages
      225-232
    • Publisher
      メジカルレビュー社
  • [Book] 顎顔面領域の不随意運動, 口と歯の事典2008

    • Author(s)
      宮脇正一, 吉田和也
    • Total Pages
      282-296
    • Publisher
      朝倉書店
  • [Remarks] 吉田和也.睡眠時無呼吸症候群の口腔内装置治療.「カラダ元気」FM845 2008年7月29日

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Published: 2011-06-18   Modified: 2016-04-21  

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