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2009 Fiscal Year Final Research Report

An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system

Research Project

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Project/Area Number 19592328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

KURITA Kenichi  Aichi Gakuin University, 歯学部, 教授 (40133483)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Kyoko  愛知学院大学, 歯学部, 講師 (40231659)
Project Period (FY) 2007 – 2009
Keywords軟骨 / TIMP / CAM / Alginate beads / ECM / IL-1β / TGF-β / OA
Research Abstract

The results of this study suggest that TIMP-1 plays a primary role in the prevention of articular cartilage destruction in its early stage but that TIMP-3 gradually takes over this role. Also, TGF-β was shown to regulate these TIMPs and act as a suppressor of articular cartilage destruction. These results suggest that TIMP-1 and TIMP-3 are closely involved in preventing the progression of joint disorders such as OA.

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Published: 2011-06-17   Modified: 2016-04-21  

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