2009 Fiscal Year Final Research Report
Role of lipid mediator in pathological mechanism of hyperalgesia
| Project/Area Number |
19603001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITO Nobuko The University of Tokyo, 医学部附属病院, 講師 (80332609)
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| Co-Investigator(Kenkyū-buntansha) |
TYOU Kyouhiro 東京大学, 医学部附属病院, 講師 (50302708)
ASAHARA Miho 東京大学, 医学部附属病院, 助教 (60529155)
MUROYA Mitsuaki 東京大学, 医学部附属病院, 助教 (90431866)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脂質 / 神経科学 / 炎症 |
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| Research Abstract |
Leukotriene B4 (LTB4) is a potent lipid mediator enhancing recruitment and activation of neutrophil, which is a common feature of inflammation. To elucidate the role of LTB4 in inflammatory pain, we use BLT1 (LTB4 receptor 1) deficiency mice and compared the acute pain behavior with wild type mice using intraplantarly injection of formalin or capsaicin. Compared with wild type mice, BLT1 deficiency mice exhibit attenuated pain behaviors in this model. These results indicate that BLT1 has a crucial role in the modulation of inflammatory pain. We investigate the role of LTB4 in postoperative incisional pain as a tissue injury-induced pain model. Compared with wild-type mice, BLT1 deficiency mice displayed attenuated allodynia in incised hind-paw. Our results suggest that BLT1 may play an important role in pain after tissue injury.
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