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2011 Fiscal Year Final Research Report

Strategy for producing a variety type of neurons by regulating spatial and temporal identities of neural stem cells

Research Project

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Project/Area Number 19670002
Research Category

Grant-in-Aid for Young Scientists (S)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionNational Center of Neurology and Psychiatry (2008-2011)
Kyoto University (2007)

Principal Investigator

HOSHINO Mikio  独立行政法人国立精神・神経医療研究センター, 神経研究所病態生化学研究部, 部長 (70301273)

Project Period (FY) 2007 – 2011
Keywords神経発生 / 分化 / 異常
Research Abstract

We clarified that two bHLH transcription factors(TFs), Math1 and Ptf1a, are involved in specifying the spatial identities of neural stem cells in the cerebellar primordium. We also found similar roles for these TFs in the hindbrain. Neural stem cells in the Ptf1a-expressing ventricular zone change their temporal identity ; while they produce Purkinje cells at early stages, they become to generate Pax2 positive interneurons at late stages. We clarified that two TFs, Olig2 and Gsh1, are involved in regulating temporal identity of neural stem cells in the cerebellar ventricular zone.

  • Research Products

    (36 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (7 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Origin of the brush cell lineage in the mouse intestinal epithelium2012

    • Author(s)
      Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martin MG, Chen H
    • Journal Title

      Dev. Biol

      Volume: 362 Pages: 194-218

    • DOI

      DOI:10.1016/j.ydbio.2011.12.009

    • Peer Reviewed
  • [Journal Article] Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells2011

    • Author(s)
      Goto A, Hoshino M, Matsuda M, Nakamura T
    • Journal Title

      Mol. Biol. Cell

      Volume: 22 Pages: 1780-1792

    • DOI

      DOI:10.1091/mbc.E10-09-0783

    • Peer Reviewed
  • [Journal Article] RBP-J promotes the maturation of neuronal progenitors2011

    • Author(s)
      Komine O, Nagaoka M, HIraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K
    • Journal Title

      Dev. Biol

      Volume: 354 Pages: 44-54

    • DOI

      DOI:10.1016/j.ydbio.2011.03.020

    • Peer Reviewed
  • [Journal Article] Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice2011

    • Author(s)
      Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 4176-4192

    • DOI

      DOI:10.1128/MCB.05370-11

    • Peer Reviewed
  • [Journal Article] 小脳発達の分子機構と小脳無形成モデルマウス"セレベレス"2011

    • Author(s)
      星野幹雄
    • Journal Title

      医学のあゆみ

      Volume: 239, 6 Pages: 670-474

    • Peer Reviewed
  • [Journal Article] Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-Cadherin trafficking2010

    • Author(s)
      Kawauchi T, Sekine K, Shikanai M, Chihama K, Tomita K, Nakajima K, Nabeshima Y, Hoshino M
    • Journal Title

      Neuron

      Volume: 67 Pages: 588-602

    • DOI

      DOI:10.1016/j.neuron.2010.07.007

    • Peer Reviewed
  • [Journal Article] Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex2010

    • Author(s)
      Nishimura YV, Sekine K, Chihama K, Nakajima K, Hoshino M, Nabeshima Y, Kawauchi T
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 5878-5887

    • DOI

      DOI:10.1074/jbc.M109.033761

    • Peer Reviewed
  • [Journal Article] Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system2010

    • Author(s)
      Nishida K, Hoshino M, Kawaguchi Y, Murakami F
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 373-380

    • DOI

      DOI:10.1074/jbc.M109.060657

    • Peer Reviewed
  • [Journal Article] Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh12009

    • Author(s)
      Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M
    • Journal Title

      Development

      Volume: 136 Pages: 2049-2058

    • DOI

      DOI:10.1242/dev.033480

    • Peer Reviewed
  • [Journal Article] The p21-activated kinase is required for neuronal migration in the cerebral cortex2009

    • Author(s)
      Causeret F, Terao M, Jacobs T, Nishimura YV, Yanagawa Y, Obata K, Hoshino M, Nikolic M
    • Journal Title

      Cerebral Cortex

      Volume: 19 Pages: 861-875

    • DOI

      DOI:10.1093/cercor/bhn133

    • Peer Reviewed
  • [Journal Article] Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening2009

    • Author(s)
      Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, OkazawaH, Nabeshima Y
    • Journal Title

      PloS ONE

      Volume: 4 Pages: e4466

    • DOI

      DOI:10.1371/journal.pone.0004466

    • Peer Reviewed
  • [Journal Article] Upregulation of PIP3-dependent Rac exchanger 1(P-Rex1) promotes prostate cancer metastasis2009

    • Author(s)
      Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin M-F, Tu Y
    • Journal Title

      Oncogene

      Volume: 28 Pages: 1853-1863

    • DOI

      DOI:10.1038/onc.2009.30

    • Peer Reviewed
  • [Journal Article] Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae2009

    • Author(s)
      Ono K, Nakagawa T, Kojima K, Matsumoto M, Kawauchi T, Hoshino M, Ito J
    • Journal Title

      Mol Cell Neurosci

      Pages: 42391-398

    • DOI

      DOI:10.1016/j.mcn.2009.08.011

    • Peer Reviewed
  • [Journal Article] Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice2008

    • Author(s)
      Fukuda A, Kawaguchi Y, Furuyama F, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CVE, Hoshino M, Chiba T, Uemoto S
    • Journal Title

      Diabetes

      Volume: 57 Pages: 2415-2429

    • DOI

      DOI:10.2337/db07-1558

    • Peer Reviewed
  • [Journal Article] Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons2008

    • Author(s)
      Kawauchi T, Hoshino M
    • Journal Title

      Developmental Neuroscience

      Volume: 30 Pages: 36-46

    • DOI

      DOI:10.1159/000109850

    • Peer Reviewed
  • [Journal Article] 小脳っていらないの2008

    • Author(s)
      星野幹雄
    • Journal Title

      細胞工学

      Volume: 27 Pages: 649

    • Peer Reviewed
  • [Journal Article] 小脳および前小脳システム神経細胞のサブタイプ決定機構2008

    • Author(s)
      星野幹雄
    • Journal Title

      蛋白質核酸酵素2008年3月号増刊「神経の分化、回路形成、機能発現」

      Volume: 4 Pages: 343-349

    • Peer Reviewed
  • [Journal Article] Origin of climbing fiber neurons and their developmental dependence on Ptf1a2007

    • Author(s)
      Yamada M, Terao M, Terashima T, Fujiyama T, Kawaguchi Y, Nabeshima Y, Hoshino M
    • Journal Title

      J. Neurosci

      Volume: 27 Pages: 10924-10934

    • DOI

      DOI:10.1523/JNEUROSCI.1423-07.2007

    • Peer Reviewed
  • [Journal Article] Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent proteini kinase CLICK-III/CaMKIγ2007

    • Author(s)
      Takemoto-Kimura S, Ishihara-Ageta N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H
    • Journal Title

      Neuron

      Volume: 54 Pages: 755-770

    • DOI

      DOI:10.1016/j.neuron.2007.05.021

    • Peer Reviewed
  • [Journal Article] Opposing roles in neurite growth control by two 7-pass transmembrane cadherins2007

    • Author(s)
      Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T
    • Journal Title

      Nature Neuroscience

      Volume: 10 Pages: 963-969

    • DOI

      DOI:10.1038/nn1933

    • Peer Reviewed
  • [Journal Article] Localized activation of p21-activated kinase controls neuronal polarity and morphology2007

    • Author(s)
      Jacobs T, Causeret F, Nishimura YV, Terao M, Norman A, Hoshino M, Nikolic M
    • Journal Title

      J. Neurosci

      Volume: 27 Pages: 8604-8615

    • DOI

      DOI:10.1523/JNEUROSCI.0765-07.2007

    • Peer Reviewed
  • [Journal Article] Neurabin-I is phosphorylated by Cdk5 : implications for neuronal morphogenesis and cortical migration2007

    • Author(s)
      Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M
    • Journal Title

      Molecular Biol. Cell

      Volume: 18 Pages: 4327-4342

    • DOI

      DOI:10.1091/mbc.E07-04-0372

    • Peer Reviewed
  • [Journal Article] Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function2007

    • Author(s)
      Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM
    • Journal Title

      J. Leukocyte Biol

      Volume: 81 Pages: 1127-1136

    • DOI

      DOI:10.1189/jlb.0406251

    • Peer Reviewed
  • [Journal Article] GABAergic neuron specification in the spinal cord, the cerebellum and the cochlear nucleus

    • Author(s)
      Hori K, Hoshino M
    • Journal Title

      Neural Plasticity

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Neuronal subtype specification in the cerebellum and dorsal hindbrain

    • Author(s)
      Hoshino M
    • Journal Title

      Dev Growth Differ

      Volume: (in press)

    • DOI

      DOI:10.1111/j.1440-169X.2012.01330.x

    • Peer Reviewed
  • [Journal Article] Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse

    • Author(s)
      Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H
    • Journal Title

      Science Signaling

      Volume: 4(179)

    • DOI

      DOI:10.1126/scisignal.2001127

    • Peer Reviewed
  • [Presentation] Roles of transcription factors in specifying neuron subtypes in the cerebellar system2011

    • Author(s)
      Hoshino M
    • Organizer
      4^<th> International symposium, Society for Research on the Cerebellum(第4回国際小脳学会)
    • Place of Presentation
      東京
    • Year and Date
      2011-09-18
  • [Presentation] Neuroepithelilal domain formation and neuron subtype specification in the cerebellum2010

    • Author(s)
      Hoshino M
    • Organizer
      Neuro 2010,シンポジウム"Cerebellar development : from cytogenesis and layering to topographic circuit formation日本神経科学会・日本神経化学学会合同年会
    • Place of Presentation
      神戸
    • Year and Date
      20100902-04
  • [Presentation] Roles of transcription factors in specifying neuron subtypes in the cerebellar system2010

    • Author(s)
      Hoshino M
    • Organizer
      4th International Symposium of the Society for Research on the Cerebellum
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-09-18
  • [Presentation] 後脳神経細胞の個性獲得の分子機構2009

    • Author(s)
      星野幹雄
    • Organizer
      第五回プロテオミクス・構造生物学講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-03
  • [Presentation] 小脳および前小脳システム神経細胞のサブタイプ決定機構2008

    • Author(s)
      星野幹雄
    • Organizer
      日本顕微鏡学会,第52回シンポジウム
    • Year and Date
      2008-10-18
  • [Presentation] 神経細胞の特異性獲得と移動の分子機構2008

    • Author(s)
      星野幹雄
    • Organizer
      第3回プロテオミクス・構造生物学講演会
    • Place of Presentation
      岡崎
    • Year and Date
      2008-01-13
  • [Presentation] Molecular strategy to produce a variety types of neurons2007

    • Author(s)
      Hoshinio M
    • Organizer
      BMB2007,第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
  • [Book] 小脳皮質のないマウス「セレベレス」モデル動物利用マニュアル2011

    • Author(s)
      星野幹雄
    • Total Pages
      269-276
    • Publisher
      (株)エルアイシー
  • [Book] Specification of cerebellar and precerebellar neurons

    • Author(s)
      Hoshino M, Seto Y, Mayumi Y
    • Publisher
      Springer
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nin/guide/r_diag/index.html

URL: 

Published: 2013-07-31  

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