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2009 Fiscal Year Self-evaluation Report

Elucidation for the role of heparan sulfate in neural crest cell differentiation and establishment of a new concept for glaucoma pathogenesis

Research Project

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Project/Area Number 19679008
Research Category

Grant-in-Aid for Young Scientists (S)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionUniversity of Fukui (2010-2011)
Kumamoto University (2007-2009)

Principal Investigator

INATANI Masaru  Kumamoto University, 医学部附属病院, 講師 (40335245)

Project Period (FY) 2007 – 2011
Keywords眼科学
Research Abstract

(1)隅角線維柱帯組織の機能低下は、眼圧を上昇させ、緑内障の病状を進行させる。隅角線維柱帯組織の構成成分であるヘパラン硫酸の隅角線維柱帯組織における役割を解明する。
(2)緑内障手術治療に対する手術補助薬としてのヘパラン硫酸の効果を検証する。
(3)隅角線維柱帯組織の発生に必須の分子を新たに同定する。

  • Research Products

    (13 results)

All 2010 2009 2008 2007 Other

All Journal Article (11 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis2010

    • Author(s)
      Iwao K, Inatani M, et al.
    • Journal Title

      Experimental Eye Research 90

      Pages: 81-88

  • [Journal Article] Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-β_2 signaling2009

    • Author(s)
      Iwao K, Inatani M, et al.
    • Journal Title

      Journal of Clinical Investigation 119

      Pages: 1997-2008

  • [Journal Article] Trabeculectomy with mitomycin C for neovascular glaucoma : Prognostic factors for surgical failure2009

    • Author(s)
      Takihara Y, Inatani M, et al.
    • Journal Title

      American Journal of Ophthalmology 147

      Pages: 912-918

  • [Journal Article] Restricted post-trabeculectomy bleb formation by conjunctival scarring2009

    • Author(s)
      Iwao K, Inatani M, et al.
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology 247

      Pages: 1095-1101

  • [Journal Article] Intraocular pressure elevation after injection of triamcinolone acetonide : A multicenter retrospective case-control study2008

    • Author(s)
      Inatani M, Iwao K, et al.
    • Journal Title

      American Journal of Ophthalmology 145

      Pages: 676-681

  • [Journal Article] Fate mapping of neural crest cells during eye development using a Protein 0 promoter-driven transgenic technique2008

    • Author(s)
      Iwao K, Inatani M, et al.
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology 246

      Pages: 1117-1122

  • [Journal Article] Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in normal volunteers2008

    • Author(s)
      Tanihara H, Inatani M, et al.
    • Journal Title

      Archives of Ophthalmology 126

      Pages: 309-315

  • [Journal Article] Netrin-1/DCC signaling in commissural axon guidance requires cell autonomous expression of heparan sulfate2007

    • Author(s)
      Matsumoto Y, Irie F, Inatani M, et al.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 4342-4350

  • [Journal Article] Frequency and risk factors for intraocular pressure elevation after posterior sub-Tenon's capsule triamcinolone acetonide injection2007

    • Author(s)
      Iwao K, Inatani M, et al.
    • Journal Title

      Journal of Glaucoma 16

      Pages: 251-256

  • [Journal Article] Effects of topical administration of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys2007

    • Author(s)
      Tokushige H, Inatani M, et al.
    • Journal Title

      Investigative Ophthalmology & Visual Science 48

      Pages: 3216-3222

  • [Journal Article] Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma

    • Author(s)
      Takihara Y, Inatani M, et al.
    • Journal Title

      Journal of Glaucoma (In press)

  • [Presentation] 眼発生の分子メカニズムの探究と眼疾患モデルへの展開2009

    • Author(s)
      稲谷大
    • Organizer
      「眼疾患と動物モデル」第113回日本眼科学会総会
    • Place of Presentation
      東京都
    • Year and Date
      20090416-20090419
  • [Remarks] ホームページ

    • URL

      http://www2.kuh.kumamoto-u.ac.jp/ganka/kyousitu/staff.html#inatani

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Published: 2011-06-18   Modified: 2016-04-21  

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