2009 Fiscal Year Final Research Report
Development of mucoadhesive oral patches for diabetes care
| Project/Area Number |
19760556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Oita University |
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Principal Investigator |
TOORISAKA Eiichi Oita University, 工学部, 助教 (40363543)
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| Project Period (FY) |
2007 – 2009
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| Keywords | インスリン / ドラッグデリバリー / 経口投与 / 粘膜付着性 / 糖尿病 |
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| Research Abstract |
An oral dosage form of insulin is thus desirable to achieve a safe and convenient insulin delivery that leads to high patient compliance. However, there are several barriers for the oral delivery of insulin such as enzymatic degradation in the gastrointestinal (GI) tract and low permeability across the intestinal mucosa. In this study, a new type of mucoadhesive patches for oral insulin dosage was prepared. The advantages of the mucoadhesive patch system are as follows: (1) patch can maintain its position in small intestine for a few hours; (2) drug release is a unidirectional way toward intestine mucosa ; (3) drug impermeant layer can protect from degradation by proteolytic enzymes.
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