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2008 Fiscal Year Annual Research Report

固形腫瘍に対する光線力学療法剤を志向した活性酸素発生物質の開発

Research Project

Project/Area Number 19790043
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

中西 郁夫  National Institute of Radiological Sciences, 重粒子医科学センター, 主任研究員 (70356137)

Keywords癌 / 薬学 / 有機化学 / 活性酸素 / 放射線 / ラジカル / 光線力学療法 / 反応機構
Research Abstract

前年度に引き続き、種々の置換基RをもつピリジンN-オキシド(RPyO)の一電子還元電位(E^0_<red>)を決定するため、サイクリックボルタンメトリー法によりRPyOのサイクリックボルタモグラム(CV)を測定し、得られたE^0_<red>値を構造-活性相関のライブラリに加えた。
次に、RPyOの一電子還元剤として、ジヒドロニコチンアミドアデニンジヌクレオチド(NADH)のモデル化合物である10-メチル-9, 10-ジヒドロアクリジン(AcrH_2)の光酸化反応挙動について検討し、AcrH_2が光照射により優れた還元剤として作用することを確認した。
以上の知見に基づき、RPyO部分とAcrH_2部分を共有結合で連結した新規化合物PyO-AcrHを設計した。
PyO-AcrHの合成は現在進行中であるが、前年度から得られた予備的実験の結果から、光照射により優れた活性酸素種生成能を示すと予想される。

  • Research Products

    (19 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Book (3 results)

  • [Journal Article] Intracellular and Extracellular Redox Environment Surrounding Redox-Sensitive Contrast Agents under Oxidative Atmosphere2009

    • Author(s)
      A. Okajo, et al.
    • Journal Title

      Biol. Pharm. Bull. 32

      Pages: 535-541

    • Peer Reviewed
  • [Journal Article] Detection of Free Radical Reactions in an Aqueous Sample Induced by Low Linear-Energy-Transfer Irradiation2009

    • Author(s)
      K. Matsumoto, et al.
    • Journal Title

      Biol. Pharm. Bull. 32

      Pages: 542-547

    • Peer Reviewed
  • [Journal Article] Effect of Metal Ions on the Radical-Scavenging Rates of Hydroquinones2008

    • Author(s)
      I. Nakanishi, et al.
    • Journal Title

      J. Pharm. Soc. Jpn. 128

      Pages: 71-71

  • [Journal Article] Structure-Activity Relationship in Radical-Scavenging Reactions of Naturally-Oriented Artepillin C Derivatives2008

    • Author(s)
      I. Nakanishi, et al.
    • Journal Title

      Prog. Biochem. Biophys. 35

      Pages: 290-290

  • [Journal Article] Free Radical Reactions in an Aqueous Sample Caused by Heavy-Ion (Carbon) Beam Irradiation2008

    • Author(s)
      K. Matsumoto, et al.
    • Journal Title

      Free Radical Biol. Med. 45

      Pages: S20-S20

    • Peer Reviewed
  • [Journal Article] One-Step Hydrogen Atom Transfer in Radical-Scavenging Reactions by Artepillin C Derivatives Enhanced by Electron-Donating Groups2008

    • Author(s)
      I. Nakanishi, et al.
    • Journal Title

      Free Radical Biol. Med. 45

      Pages: S63-S63

    • Peer Reviewed
  • [Presentation] ラジカル消去活性の増強を目的としたビタミンE誘導体の開発2009

    • Author(s)
      中西郁夫 ら
    • Organizer
      第20回ビタミンE研究会
    • Place of Presentation
      奈良
    • Year and Date
      20090124-25
  • [Presentation] Free Radical Reactions in an Aqueous Sample Caused by Heavy-Ion (Carbon) Beam Irradiation2008

    • Author(s)
      K. Matsumoto, et al.
    • Organizer
      15th Annual Meeting of the Society for Free Radical Biology and Medicine
    • Place of Presentation
      米国インディアナポリス
    • Year and Date
      20081119-23
  • [Presentation] One-Step Hydrogen Atom Transfer in Radical-Scavenging Reactions by Artepillin C Derivatives Enhanced by Electron-Donating Groups2008

    • Author(s)
      I. Nakanishi, et al.
    • Organizer
      15th Annual Meeting of the Society for Free Radical Biology and Medicine
    • Place of Presentation
      米国インディアナポリス
    • Year and Date
      20081119-23
  • [Presentation] Structure-Activity Relationship in Radical-Scavenging Reactions of Naturally-Oriented Artepillin C Derivatives2008

    • Author(s)
      I. Nakanishi, et al.
    • Organizer
      XIV Biennial Meeting of the Society for Free Radial Research International
    • Place of Presentation
      北京
    • Year and Date
      20081018-22
  • [Presentation] 電子スピン共鳴(ESR)法を用いた生体関連酸化還元反応機構の解明2008

    • Author(s)
      中西郁夫
    • Organizer
      第47回電子スピンサイエンス学会年会
    • Place of Presentation
      福岡
    • Year and Date
      20081001-03
  • [Presentation] Evaluation of Antioxidative Ability of Antioxidative Food Factors by EPR Spin-Trapping, Stopped-Flow Kinetic Analysis, and Mitochondrial ROS Assay2008

    • Author(s)
      I. Nakanishi, et al.
    • Organizer
      A Joint Conference of 13th In Vivo EPR Spectroscopy & Imaging and 10th International EPR Spin Trapping/Spin Labeling
    • Place of Presentation
      福岡
    • Year and Date
      20080928-30
  • [Presentation] Detection of Heavy-Ion Particles Radiation-Generated Free Radicals and Modification of Their Biological Effects2008

    • Author(s)
      K. Anzai, et al.
    • Organizer
      A Joint Conference of 13th In Vivo EPR Spectroscopy & Imaging and 10th International EPR Spin Trapping/Spin Labeling
    • Place of Presentation
      福岡
    • Year and Date
      20080928-30
  • [Presentation] Analysis of Free Radical Reactions in an Aqueous Sample Caused by Heavy-Ion (Carbon) Beam Irradiation2008

    • Author(s)
      K. Matsumoto, et al.
    • Organizer
      A Joint Conference of 13th In Vivo EPR Spectroscopy & Imaging and 10th International EPR Spin Trapping/Spin Labeling
    • Place of Presentation
      福岡
    • Year and Date
      20080928-30
  • [Presentation] 抗酸化物質が関与するフリーラジカル反応のメカニズム解明に体する物理化学的アプローチ2008

    • Author(s)
      中西郁夫
    • Organizer
      第23回日本酸化ストレス学会関東支部会
    • Place of Presentation
      横浜
    • Year and Date
      2008-12-13
  • [Presentation] 天然抗酸化物質の生合成前駆体およびその類縁体のラジカル消去活性2008

    • Author(s)
      中西郁夫ら
    • Organizer
      第8回AOB(Antioxidant Biofactor)研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
  • [Book] ビタミンE研究の進歩XIII2009

    • Author(s)
      中西郁夫ら
    • Total Pages
      4
    • Publisher
      ビタミンE研究会
  • [Book] XIV Biennial Meeting of the Society for Free Radical Research International2009

    • Author(s)
      I. Nakanishi, et al.
    • Total Pages
      4
    • Publisher
      International Proceedings
  • [Book] 第6回AOB研究会プロシーディング2008

    • Author(s)
      川島知憲ら
    • Total Pages
      4
    • Publisher
      AOB研究会

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Published: 2010-06-11   Modified: 2016-04-21  

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