2009 Fiscal Year Self-evaluation Report
The development of the polysomal RNA vaccine to the ovarian cancer
| Project/Area Number |
19791178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kurume University |
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Principal Investigator |
TSUDA Naotake Kurume University, 医学部, 助教 (60341351)
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| Project Period (FY) |
2007 – 2010
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| Keywords | RNA / 癌ワクチン |
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| Research Abstract |
我々の研究は、卵巣癌由来polysomal RNA (RNA peptide複合体)を用いた既存の癌ワクチンと異なる、全く新しい癌ワクチン療法の開発を目的とする。さらにpaclitaxelによるpolysomal RNAの免疫、分子修飾効果を検討し、より強力な細胞傷害性Tリンパ球(CTL), Natural Killer cell(NK cell)誘導能をもつRNA peptide複合体の開発を研究目的とする
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[Journal Article] N-terminally LRMK-linked HER-2 peptides, AE-37 [p776(774-788)] and AE-47 [Ava-F7(776-788)], aid differentiation of E75-TCR+CD8+ cells to perforin-positive cells.2009
Author(s)
Matsueda S, Gao H, Efferson CL, Tsuda N, Ishiyama S, Li Y, Ioannides MG, Fisk B, Peoples GE, Ioannides CG
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Journal Title
Anticancer Research 29(7)
Pages: 2427-2435
Peer Reviewed
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[Journal Article] Distinct patient responses to activation of T-cells by free HER-2, G89 (777-789) and protected LRMK-linked HER-2, {AE-39 [p776 (Ava-774-788)], AE-47 [(Ava-776-788)] and AE-37[p776 (774-788)]} peptides could lead to development of personalized cancer vaccines2009
Author(s)
Li Y, Matsueda S, Efferson CL, Tsuda N, Kawano K, Gao H, Peoples GE, Ioannides CG.
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Journal Title
Anticancer Research 29(1)
Pages: 41-58
Peer Reviewed
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