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2008 Fiscal Year Final Research Report

Enhancement of memory acquisition by chewing : a multimodal brain imaging study

Research Project

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Project/Area Number 19791374
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

ONO Yumie  Kanagawa Dental College, 歯学部, 講師 (10360207)

Project Period (FY) 2007 – 2008
Keywords口腔生理学 / 咀嚼 / 記憶 / 海馬 / 脳磁図 / fMRI / 拡散スペクトラムイメージング
Research Abstract

近年,咀嚼が認知症の予防法として注目されている。本研究は,脳活動を計測するfMRI・MEGと,脳内の神経連絡を描出するDSIを併用したヒト脳マルチモダリティ計測によって,記憶獲得・想起時における「記憶回路」の解明,そしてこれらにおけるガムチューイングの効果を評価した。その結果,(1)視覚的記憶課題遂行において,一次視覚野を介した脳内記憶回路が存在し,後頭部α波活動が課題遂行における記憶負荷を表すこと,(2)ガムチューイングは,記憶課題遂行に伴う記憶負荷の増加を抑え,記憶活動を長時間,円滑に維持させることが明らかとなった。これらの成果は,廃用性認知症対策としての咀嚼刺激の有用性を裏付けている。

  • Research Products

    (13 results)

All 2008 2007 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Chewing ameliorates stress-induced suppression of hippocampal long-term potentiation2008

    • Author(s)
      Ono Y, Kataoka T, Miyake S, Cheng SJ, Tachibana A, Sasaguri K, Onozuka M
    • Journal Title

      Neuroscience 154(2)

      Pages: 1352-1359

    • Peer Reviewed
  • [Journal Article] Continuous observation on heart-disease- model mice using biomagnetic measurement system2008

    • Author(s)
      Kasai Y, Oikawa T, Saitoh Y, Ono Y, Ishiyama A, Kasai N, Odawara A, Chinone K
    • Journal Title

      Journal of Physics : Conference Series (JPCS) 97

      Pages: 012239 (Online journal)

    • Peer Reviewed
  • [Journal Article] MCG on heart disease modified mice2007

    • Author(s)
      Kako M, Kimura T, Kamiyama H, Ono Y, Ishiyama A, Kasai N
    • Journal Title

      International Congress Series 1300

      Pages: 496-499

    • Peer Reviewed
  • [Presentation] Effects of gum chewing on alpha band activity during human working memory : a magnetoencephalographic study2008

    • Author(s)
      Dowaki K
    • Organizer
      16th International Conference on Biomagnetism
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-08-26
  • [Presentation] Tracking the cerebro-cerebellar verbal working memory circuitry using functional MRI and Diffusion Spectrum Imaging2008

    • Author(s)
      Yu JS
    • Organizer
      14th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2008-07-15
  • [Presentation] Chewing rescues stress- attenuated hippocampal memory by reducing stress2008

    • Author(s)
      Ono Y
    • Organizer
      86th International Association for Dental Research general session
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-04
  • [Presentation] 咀嚼が脳活動に及ぼす影響-短期記憶課題実行時のMEG計測による検討-2007

    • Author(s)
      堂脇可菜子
    • Organizer
      電気学会マグネティックス研究会
    • Place of Presentation
      東京大学柏キャンパス
    • Year and Date
      2007-09-21
  • [Presentation] Ameliorative effect of biting on the stress-attenuated hippocampal memory process : A Morris water maze study2007

    • Author(s)
      Miyake S
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-11
  • [Presentation] Ameliorative effect of biting on the stress-attenuated hippocampal memory process : A CA1-LTP study2007

    • Author(s)
      Ono Y
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-11
  • [Presentation] ガムチューイングが短期記憶獲得時のθ波活動に及ぼす影響2007

    • Author(s)
      堂脇可菜子
    • Organizer
      第22回日本生体磁気学会大会
    • Place of Presentation
      生理学研究所(岡崎)
    • Year and Date
      2007-06-21
  • [Book] Magnetoencephalography : basic theory and estimation techniques of working brain activity, in Novel Trends in Brain Science2007

    • Author(s)
      Ono Y and Ishiyama A
    • Total Pages
      77-93
    • Publisher
      Springer
  • [Book] Interactions between chewing and brain activities in humans, in Novel Trends in Brain Science2007

    • Author(s)
      Onozuka M, Hirano Y, Tachibana A, Kim W, Ono Y, Sasaguri K, Kubo K, Niwa M, Kanematsu K and Watanabe K
    • Total Pages
      99-113
    • Publisher
      Springer
  • [Remarks] 神奈川歯科大学高次脳・口腔科学研究センター

    • URL

      http://www.kdcnet.ac.jp/college/rcbos/index.html

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Published: 2010-06-10   Modified: 2016-04-21  

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