Investigation on the association between periodontal disease and silent cerebrovascular lesions in a community-dwelling population.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19791629
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: OHI Takashi Tohoku University, 大学院・歯学研究科, 助教 (10396450)
• Co-Investigator(Renkei-kenkyūsha): MIYOSHI Yoshitada 東北大学, 大学病院, 医員 (10508948) ; ITABASHI Shiho (高橋 志保) 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (80451607) ; MURAKAMI Takahisa 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70451606)
• Project Period (FY): 2007 – 2009
• Keywords: 疫学 / 歯周病 / 無症候性脳血管障害 / ラクナ梗塞 / 白質病変 / 一般住民

Research Abstract

The purpose of this cross-sectional cohort study was to examine the association between periodontal disease and silent cerebrovascular lesions. The study cohort comprised 230 individuals at least 55 years of age residing in Ohasama, rural community in northern Japan. Subjects underwent periodontal examination and were classified into 4 groups depending on the periodontal and dentate status (normal/slight, moderate and severe peirodontitis and <10 teeth group). The association between periodontal disease and silent cerebrovascular lesions (white matter hyperintensity and lacunar infarcts) was explored by multivariate logistic regression analysis adjusted for age; gender; body mass index; smoking; alcohol consumption; and a history of hypertension, diabetes, and hypercholesterolemia. The proportions of individuals with silent cerebrovascular lesions gradually increased with a severer periodontal status. The odds ratio for the presence of lacunar infarct in severe periodontal status (OR=12.6) was significantly higher than that in the nomal/slight periodontal status (Reference). This result suggests that periodontal disease may be associated with an increased risk of silent cerebrovascular lesions.

Research Products

• [Journal Article] 中高齢者の抑うつに関わる歯科的要因:大迫研究. (2008)
  • Author(s): 大井孝, 栗本鮎美, 板橋志保, 三好慶忠, 水戸祐子, 水尻大希, 服部佳功, 伊藤理恵, 鈴木和広, 細川彩, 平野幹雄, 大久保孝義, 細川徹, 粟田主一, 今井潤, 渡邉誠
  • Journal Title: 老年歯科医学 23巻3号 Pages: 308-318
  • Peer Reviewed
• [Journal Article] 無症候性脳血管障害と口腔状態との関連-大迫研究-. (2007)
  • Author(s): 大井孝, 竹島秀俊, 三好慶忠, 高橋志保, 熊谷崇
  • Journal Title: 高齢者歯科医療懇話会誌 10巻1号 Pages: 41-47
• [Presentation] Association of Periodontal Disease with Atherosclerosis: the Ohasama Study. (2009)
  • Author(s): S Itabashi, T Ohi, T Murakami, H Mizushiri, M Kikuya, T Ohkubo, J Hashimoto, Y Imai, M Watanabe
  • Organizer: 87th General Session & Exhibition of the IADR
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 20090401-20090404
• [Presentation] 中高齢者における抑うつスコアの高値に関わる歯科的要因:大迫研究 (2007)
  • Author(s): 大井孝, 伊藤進太郎, 山口哲史, 菊池雅彦, 服部佳功, 福田寛, 星晴久, 今井潤, 渡邉誠
  • Organizer: 第18回日本老年歯科医学会
  • Place of Presentation: 札幌
  • Year and Date: 20070620-20070622
• [Book] 財団法人8020推進財団, 東京. はち・まる・にい・まる(8020)「歯周病と脳血管疾患」 (2008)
  • Author(s): 渡邉誠, 大井孝
  • Total Pages: 32-35
• [Book] 財団法人社会福祉振興・試験センター, 東京. 「介護福祉」夏季号No. 66. 「無症候性脳血管障害と口腔状態との関連-大迫研究から-」 (2007)
  • Author(s): 渡邉誠, 大井孝
  • Total Pages: 125-131
• [Book] 大阪. 咀嚼が創る健康長寿「噛み合わせと脳」 (2007)
  • Author(s): 渡邉誠, 伊藤進太郎, 大井孝
  • Total Pages: 120-126
  • Publisher: 大阪大学出版会