酸素や食物が内包する毒性に対する細胞の適応・応答の分子機構の解明

2007 Fiscal Year Annual Research Report

• Project/Area Number: 19GS0312
• Research Institution: Tohoku University
• Principal Investigator: 山本 雅之 Tohoku University, 大学院・医学系研究科, 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): 勝岡 史城 筑波大学, 大学院・人間総合科学研究科, 助教 (30447255)
• Keywords: 発現制御 / 環境 / ストレス / 遺伝子

Research Abstract

生体は,食物および酸素の内包する毒性やそれらの過不足といった環境ストレスに対して,応答して恒常性を維持している.本研究では,環境応答転写制御におけるストレスセンサーの分子機構を明らかにする事を目的としている
Nrf2-Keap1システムによる親電子性物質・酸化ストレス感知機構の解析:本年度は,ストレスセンサーとして働くKeap1-Nrf2複合体の結晶構造解析を目的として,これら分子を大腸菌発現系にて発現・精製した.現在,結晶化の条件を検討している.動物個体レベルの解析として,Keap1あるいは,その変異体を発現するトランスジェニックマウスを作製し,Keap1欠損マウスの表現型のレスキュー解析を行った.その結果,Keap1の複数のシステイン残基が,親電子性試薬の応答に必須であり,それぞれ性質が異なることが明らかとなった.
Epo遺伝子制御機構の解析よる低酸素感知機構の解析:Epo遺伝子の制御機構の解析を解析することで,腎臓での新たな低酸素応答の分子機構を明らかにすることを目的とし.今年度は,同遺伝子制御領域を含む大腸菌人工染色体(BAC)に緑色蛍光蛋白質(GFP)遺伝子を組み込み,レポータートランスジェニックマウスを作製した.その結果,Epo遺伝子転写制御領域に,これまで知られている低酸素応答領域とは別の,腎臓特異的・低酸素応答性の転写制御領域が存在することを明らか,その領域の範囲を2kbpにまで狭めることに成功した.

Research Products

• [Journal Article] Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t (9;9) -derived fusion gene product, SET/TAF-Ib-CAN/Nup214. (2008)
  • Author(s): Saito S, Nouno K, Shimizu R, Yamamoto M, and Nagata K.
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• [Journal Article] GATA-1の機能異常と白血病-Leukemogenesis related to GATA-1 mutation- (2008)
  • Author(s): 安倍加奈子、清水律子、山本雅之
  • Journal Title: 日本産婦人科血液学会誌 17 Pages: 1-8
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• [Journal Article] Characterization of GATA-1^+ hemangioblastic cells in the mouse embryo. (2007)
  • Author(s): Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato. M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, and Yamamoto M.
  • Journal Title: EMBO J. 26 Pages: 184-196
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• [Journal Article] Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f] quinoline. (2007)
  • Author(s): Kitamura Y, Umemura T, Kanki K, Kodama Y, Kitamoto S, Saito K, Itoh K, Yamamoto M, Masegi T, Nishikawa A, and Hirose M.
  • Journal Title: Cancer Sci. 98 Pages: 19-24
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• [Journal Article] Shear stress stabilizes NF-E2 related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species. (2007)
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  • Journal Title: Free Rad Biol Med. 42 Pages: 260-269
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• [Journal Article] Inchinkoto, an herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. (2007)
  • Author(s): Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y and Suzuki H.
  • Journal Title: Am J Physiol Gastrointestinal Liver Physiol. 295 Pages: 1450-1463
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• [Journal Article] Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. (2007)
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  • Journal Title: Mol Cancer Therapeutics. 6 Pages: 154-161
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• [Journal Article] Does K-11706 enhance performance and why? (2007)
  • Author(s): Imagawa S, Matsumoto K, Horie M, Ohkoshi N, Nagasawa T, Doi T, Suzuki N, and Yamamoto M.
  • Journal Title: Int J Sports Med. 28 Pages: 928-933
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• [Journal Article] Functional polymorphisms in the transcription factor NRF2 increase the risk of acute lung injury. (2007)
  • Author(s): Marzec JM, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho, H-Y, and Kleeberger SR.
  • Journal Title: FASEB J. 21 Pages: 2237-2246
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• [Journal Article] Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22)acute myeloid leukemia. (2007)
  • Author(s): Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, and Osato M.
  • Journal Title: Blood. 109 Pages: 4023-4027
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• [Journal Article] Cell cycle-dependent oscillation of GATA2 expression in hematopoietic cells. (2007)
  • Author(s): Koga S, Yamaguclu N, Abe T, Minegishi M, Tsuchiya S, Yamamoto M, and Minegishi N.
  • Journal Title: Blood. 109 Pages: 4200-4208
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• [Journal Article] Dynamic regulation of Gata factor levels is more important than their identity. (2007)
  • Author(s): Ferreira R, Wai A, Shimizu R, Gillemans N, Rottier R, von Lindem M, Ohneda K, Grosveld F, Yamamoto M, and Philip sen S.
  • Journal Title: Blood. 109 Pages: 5481-5490
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• [Journal Article] Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. (2007)
  • Author(s): Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, and Yamamoto M.
  • Journal Title: Biochem J. 404 Pages: 459-466
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• [Journal Article] A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. (2007)
  • Author(s): Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim K-C, and Engel JD.
  • Journal Title: Development. 139 Pages: 1703-1712
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• [Journal Article] Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. (2007)
  • Author(s): Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD.
  • Journal Title: EMBO J. 26 Pages: 2295-2306
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• [Journal Article] GATA-1 self-association controls erythroid development in vivo. (2007)
  • Author(s): Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, and Yamamoto M.
  • Journal Title: J Biol Chem. 282 Pages: 15862-15871
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• [Journal Article] Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. (2007)
  • Author(s): Reddy NM, Kleeberger SR, Cho H-Y, Yamamoto M, Kensler TW, Biswal S, and Reddy SP.
  • Journal Title: Am J Res Cell Mol Biol. 37 Pages: 3-8
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• [Journal Article] Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. (2007)
  • Author(s): Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S.
  • Journal Title: Neuroscience. 147 Pages: 53-59
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• [Journal Article] Enhanced spontaneous and benzo[α]pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. (2007)
  • Author(s): Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Hiyoshi K, Takano H, Masumura K, Itoh K, Nohmi T and Yamamoto M.
  • Journal Title: Cancer Res. 67 Pages: 5643-5648
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• [Journal Article] Oxidative and electrophilic stress induces Mrp transporters via the Nrf2 transcriptional pathway. (2007)
  • Author(s): Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, and Klaassen CD.
  • Journal Title: Hepatology. 46 Pages: 1597-1610
  • Peer Reviewed
• [Journal Article] Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. (2007)
  • Author(s): Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S.
  • Journal Title: Free Rad Biol Med. 43 Pages: 408-414
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• [Journal Article] Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. (2007)
  • Author(s): Iida K, Itoh K, Maher JM, Kumagai Y, Oyasu R, Mori Y, Fukushima S, Shimazui T, Akaza H, and Yamamoto M.
  • Journal Title: Carcinogenesis. 28 Pages: 2398-2403
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• [Journal Article] NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis. (2007)
  • Author(s): Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, and Kensler TW.
  • Journal Title: Mol Cell Biol. 27 Pages: 7188-7197
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• [Journal Article] Different Electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. (2007)
  • Author(s): Tong KI, Padmanabhan B, Kobayashi A, Shang C, Hirotsu Y, Yokoyama S, and Yamamoto M.
  • Journal Title: Mol Cell Biol. 27 Pages: 7511-7521
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• [Journal Article] Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. (2007)
  • Author(s): Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, and Kensler TW.
  • Journal Title: Int J Cancer. 121 Pages: 1883-1891
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• [Journal Article] Subcellul localization and cytoplasmic complex status of endogenous Keapl. (2007)
  • Author(s): Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, and Yamamoto M.
  • Journal Title: Genes Cells. 12 Pages: 1163-1178
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• [Journal Article] In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-lc expression. (2007)
  • Author(s): Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y. Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga JI. and Shimano H.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 329-335
  • Peer Reviewed
• [Journal Article] Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. (2007)
  • Author(s): Toyama T, Sumi D, Shinkai Y, Yasutake A, Taguchi K, Tong KI, Yamamoto M, and Kumagai Y.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 645-650
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• [Journal Article] Potential involvement of pathophysiologically formed 8-nitroguanosine 3',5'-cyclic monophosphate in nitric oxide-induced signal transduction. (2007)
  • Author(s): Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, and Akaike T.
  • Journal Title: Nature Chem Biol. 3 Pages: 727-735
  • Peer Reviewed
• [Journal Article] The N-terminal homology box 1 (NHB1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its Asn-glycosylation. (2007)
  • Author(s): Zhang Y, Lucocq JM, Yamamoto M, and Hayes JD.
  • Journal Title: Biochem J. 408 Pages: 161-172
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• [Journal Article] The TR2 and TR4 orphan nuclear receptors repress Gatal transcription. (2007)
  • Author(s): Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, and Engel JD.
  • Journal Title: Genes Dev. 21 Pages: 2832-2844
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• [Journal Article] Loss of p62/SQSTM1 suppresses cytoplasmic inclusion body formation and liver injury in autophagy-deficient mouse. (2007)
  • Author(s): Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E and Tanak
  • Journal Title: Cell. 131 Pages: 1149-1163
  • Peer Reviewed
• [Journal Article] Molecular basis distinguishing the DNA binding profile of NRF2-MAF heterodimer from that of MAF homodimer. (2007)
  • Author(s): Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, and Yamamoto M.
  • Journal Title: J Biol Chem. 282 Pages: 33681-33690
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• [Journal Article] A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts or gan protection against ischemia. (2007)
  • Author(s): Nangaku M, Izuhara Y, Takizawa S, Yamashita T, Fujii-Kuriyama Y, Ohneda O, Yamamoto M, van Ypersele de Strihou C, Hirayama N, and Miyata T.
  • Journal Title: Arterioscler Thromb Vas Biol. 27 Pages: 2548-2554
  • Peer Reviewed
• [Journal Article] Molecular mechanism of transcriptional repression of AhR repressor in volving ANKRA2, HDAC4, and HDAC5. (2007)
  • Author(s): Oshima M, Mimura J, Yamamoto M, and Fujii-Kuriyama Y.
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 276-282
  • Peer Reviewed
• [Journal Article] Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. (2007)
  • Author(s): Okitsu Y, Takahashi S, Minegishi N, Kameoka J, Kaku M, Yamamoto M, Sasaki T, and Harigae H
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 383-387
  • Peer Reviewed
• [Journal Article] Dysfunction of Nrf2 decreases KBrO_3-induced oxidative DNA damage in Ogg1-null mice. (2007)
  • Author(s): Jaloszynsk P, Murata S, Shinkai Y, Takahashi S, Kumagai Y, Nishimura S, and Yamamoto M.
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 966-971
  • Peer Reviewed
• [Journal Article] Carcinogenesis and transcriptional regulation through Maf recognition elements. (2007)
  • Author(s): Motohashi H, and Yamamoto M.
  • Journal Title: Cancer Sci. 98 Pages: 135-139
  • Peer Reviewed
• [Journal Article] Regulation of GATA1 gene expression. (2007)
  • Author(s): Kobayashi M, and Yamamoto M.
  • Journal Title: J Biochem. 142 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Use of gene manipulated mice in the study of erythropoietin gene expression. (2007)
  • Author(s): Suzuki N, Obara N, and Yamamoto M.
  • Journal Title: Methods Enzymol. 435 Pages: 157-177
  • Peer Reviewed
• [Journal Article] 酸素センシングと赤血球造血シグナル (2007)
  • Author(s): 今川重彦、小原 直、鈴木教郎、山本雅之
  • Journal Title: 細胞 39 Pages: 537-540
  • Peer Reviewed
• [Journal Article] GATA因子スイッチングとGATA-1白血病 (2007)
  • Author(s): 清水律子、山本雅之
  • Journal Title: 生化学 79 Pages: 941-952
  • Peer Reviewed
• [Journal Article] 酸化ストレス防御のための生体内センサー:Keap1-Nrf2制御システム (2007)
  • Author(s): 田口恵子、山本雅之
  • Journal Title: 化学と生物 45 Pages: 857-862
  • Peer Reviewed
• [Journal Article] 食物と酸素由来の環境ストレスを感知するセンサー系 (2007)
  • Author(s): 大辻摩希子、山本雅之
  • Journal Title: 細胞工学 12月号 Pages: 1386-1390
  • Peer Reviewed
• [Presentation] Genetic Analysis of Mouse GATA-related Leukemia and Leukemic Stem Cells. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Gordon Research Conference on Red Cells, Centre Paul Langevin in Aussois.
  • Place of Presentation: Aussois, France
  • Year and Date: 20070520-25
• [Presentation] Functional analyses of GATA-2 with knockdown and conditional knockout mice. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: EMBO WORKSHOP ON The Role and Control of GATA Factors in Tissue Development and Disease.
  • Place of Presentation: Capri, Italy
  • Year and Date: 20070414-17
• [Presentation] The environmental response to food and oxygen. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: JST-ERATO Environmental Response Project International Symposium on "The Environmental Response"
  • Place of Presentation: EPOCHAL Tsukuba International Congress Center, Tsukuba
  • Year and Date: 2007-12-21
• [Presentation] Molecular Mechanisms of Adaptive Responses to Food and Oxygen. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The International Conference on Food Factors for Health Promotion (ICOFF2007)
  • Place of Presentation: Kyoto
  • Year and Date: 2007-11-29
• [Presentation] 酸化ストレス応答の分子基盤と疾患 (2007)
  • Author(s): 山本雅之
  • Organizer: CKDと心血管イベントExpert Meeting特別講演
  • Place of Presentation: 東京會舘
  • Year and Date: 2007-11-27
• [Presentation] 親電子性物質・酸化ストレス応答の分子機構 (2007)
  • Author(s): 山本雅之
  • Organizer: 第7回 システム生物医学研究会
  • Place of Presentation: 東京大学先端科学技術研究センター システム生物医学ラボラトリー主催、箱根湯本
  • Year and Date: 2007-11-21
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 東海医学会講演会
  • Place of Presentation: 東海大学
  • Year and Date: 2007-11-13
• [Presentation] The NrF2-Keap1 Stress Response System. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The 23rd Kumamoto Medical Bioscience Symposium on New Insights into Metabolic Disorders and Vascular Disease.
  • Place of Presentation: Kumamoto
  • Year and Date: 2007-11-12
• [Presentation] GATA因子と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第2回 つくば医科学研究交流会 ランチョンセミナー
  • Place of Presentation: 三菱化学つくばクリエーションセンター
  • Year and Date: 2007-11-10
• [Presentation] Two-site substrate recognition model for the Keapl-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Distinguished Professor's Seminar.
  • Place of Presentation: University of Arizona, Tucson, USA
  • Year and Date: 2007-11-02
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Adjunct Professor Lecture at Johns Hopkins University Blumberg School of Public Health, Baltimore
  • Place of Presentation: Johns Hopkins University Blumberg School of Public Health, Baltimore, USA
  • Year and Date: 2007-10-31
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: NIEHS Seminar.
  • Place of Presentation: Research Triangle Park (RTP), USA
  • Year and Date: 2007-10-30
• [Presentation] Two-site substrate recognition model for the Keapl-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: National University of Singapore-Tohoku University/Centre of Excellence Joint Symposium "Basic and Clinical Research on Signal Transduction Diseases".
  • Place of Presentation: Centre for Life Sciences, National University of Singapore, Singapore, Singapore
  • Year and Date: 2007-09-05
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 臨床研セミナー
  • Place of Presentation: (財)東京都医学研究機構 東京都臨床医学総合研究所
  • Year and Date: 2007-08-10
• [Presentation] Two-site substrate recognition model for the Keapl-Nrf2 system: a hinge and latcn mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The 3rd DECODE for Biological Responses International Meeting.
  • Place of Presentation: Odaiba, Tokyo
  • Year and Date: 2007-08-04
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 第5回フリーラジカルと脳疾患 東日本研究会特別講演
  • Place of Presentation: 経団連会館、大手町
  • Year and Date: 2007-07-28
• [Presentation] 環境応答の分子機構 (2007)
  • Author(s): 山本雅之
  • Organizer: 第5回RCGMフロンティアシンポジウム「ゲノム医学-基礎から未来医療へ」
  • Place of Presentation: 埼玉医科大学日高キャンパス創立30周年記念講堂、日高市
  • Year and Date: 2007-07-27
• [Presentation] GATA転写因子群の機能異常と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第17回 日本産婦人科・新生児血液学会シンポジウム「ダウン症候群と一過性骨髄造血(TAM)」
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2007-06-30
• [Presentation] 細胞の癌化とその抑制における転写因子の役割 (2007)
  • Author(s): 山本雅之
  • Organizer: 文部科学省がん特定領域研究「遺伝情報システム異常と発がん」
  • Place of Presentation: 癌研究会吉田富三記念講堂、有明
  • Year and Date: 2007-06-30
• [Presentation] 親電子性物質・酸化ストレス応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 循環器内科リサーチセミナー
  • Place of Presentation: 東北大学
  • Year and Date: 2007-05-30
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 日本生化学会東北支会シンポジウム
  • Place of Presentation: 長陵会館、仙台
  • Year and Date: 2007-05-12
• [Presentation] 酸化ストレス応答と呼吸器疾患 (2007)
  • Author(s): 山本雅之
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京フォーラム
  • Year and Date: 2007-05-11
• [Presentation] GATA転写因子群の機能異常と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第50回東北小児白血病研究会
  • Place of Presentation: かんぽヘルスプラザ仙台
  • Year and Date: 2007-04-28