2011 Fiscal Year Final Research Report
Molecular Mechanisms of Adaptive Responses to Food and Oxygen
| Project/Area Number |
19GS0312
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATSUOKA Fumiki 東北大学, 大学院・医学系研究科, 准教授 (30447255)
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| Co-Investigator(Renkei-kenkyūsha) |
MINEGISHI Naoko 東北大学, 大学院・医学系研究科, 准教授 (40271895)
MOTOHASHI Hozumi 東北大学, 大学院・医学系研究科, 准教授 (00282351)
KUROKAWA Hirofumi 東北大学, 大学院・医学系研究科, 講師 (80359546)
SUZUKI Norio 東北大学, 大学院・医学系研究科, 講師 (20447254)
MORIGUCHI Takashi 東北大学, 大学院・医学系研究科, 講師 (10447253)
SUZUKI Takafumi 東北大学, 大学院・医学系研究科, 助教 (70508308)
TAGUCHI Keiko 東北大学, 大学院・医学系研究科, 助教 (20466527)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 環境応答 / Nrf2 / Keap1 / 酸化ストレス / 低酸素 / エリスロポエチン |
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| Research Abstract |
Environmental stress response system allows organisms to keep cellular homeostasis. In this study, weexamined Keap1-Nrf2-mediated oxidative and xenobiotic defense system, and identified novel molecular mechanisms for stress-sensing system and their association with diseases. We alsoidentified diverse and elaborate gene regulatory mechanisms in response to hypoxic stressthrough the comprehensive analysis of erythropoietin gene regulatory regions.
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