Peptide drugs derived from food material for periodontal disease preventing flail and AMR

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H03829
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Koichi Tabeta 新潟大学, 医歯学系, 教授 (20401763)
• Co-Investigator(Kenkyū-buntansha): 野中 由香莉 新潟大学, 医歯学総合病院, 講師 (40710520) ; 寺尾 豊 新潟大学, 医歯学系, 教授 (50397717) ; 藤本 啓二 慶應義塾大学, 理工学部(矢上), 教授 (70229045) ; 高橋 直紀 新潟大学, 医歯学系, 准教授 (80722842) ; 谷口 正之 新潟大学, 自然科学系, 教授 (00163634)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 歯周炎 / ペプチド / 抗菌活性 / バイオフィルム

Outline of Final Research Achievements

Antimicrobial control of oral bacteria is an effective approach to the prevention and treatment of periodontal disease. However, due to the increase in drug-resistant bacteria, the use of antimicrobial agents has been restricted on a global scale. In this project, we focused on functional peptides derived from rice and soybeans to create new personalized periodontal peptide drugs that specifically control oral bacteria and analyzed their functions. As a result, several food functional peptide materials with antimicrobial activity and amino acid substitutions with enhanced function were selected for the prevention and treatment of periodontal disease. The library of functional peptides provides a basis for the development of next-generation periodontal peptide medicines that are safe alternatives to existing antimicrobial agents.

Free Research Field

歯周治療学

Academic Significance and Societal Importance of the Research Achievements

既存抗生物質と異なる作用機序を有し，歯周病細菌群に対して狭域スペクトルを持つペプチド医薬開発の発展性と学術的独自性を持つ。また，アミノ酸置換によるペプチド機能強化は，ペプチドの特異性と多様性の向上を可能とした。これらの機能ペプチドコレクションは検査・診断，症状・病期・細菌叢に対応するパーソナライズド歯周病医薬開発へつながり，国民に提供する新たな個別化医療の創造性を有する。