2021 Fiscal Year Annual Research Report
Enzymes as Active Matter at Nanoscales
| Project/Area Number |
19K03765
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| Research Institution | Kanazawa University |
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Principal Investigator |
Mikhailov Alex.S 金沢大学, ナノ生命科学研究所, リサーチ・プロフェッサー (00817364)
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| Co-Investigator(Kenkyū-buntansha) |
北畑 裕之 千葉大学, 大学院理学研究院, 教授 (20378532)
好村 滋行 東京都立大学, 理学研究科, 客員教授 (90234715)
小谷野 由紀 東北大学, 理学研究科, JSPS特別研究員(PD) (50849643)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | enzymes / colloids / glasses / nonequilibrium transport |
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| Outline of Annual Research Achievements |
The execution of this project has been affected by COVID pandemic. The PI, based in Berlin and working part-time in Kanazawa, could not freely travel to Japan. Nonetheless, interesting results could be obtained. The model for operation of the dynamin molecular motor has been constructed and its simulations have been performed. Simulations with large numbers of particles have been undertaken for molecular colloids of active enzymes. The theory of molecular dancing for active mechanochemical enzymes has been developed and estimates for diffusion enhancement have been obtained.
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