Microfluidic tumor model for nanomedicine development

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05236
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 28050:Nano/micro-systems-related
• Research Institution: Rikkyo University (2020-2021); Toyo University (2019)
• Principal Investigator: Sasaki Naoki 立教大学, 理学部, 准教授 (30462691)
• Co-Investigator(Kenkyū-buntansha): 岸村 顕広 九州大学, 工学研究院, 准教授 (70422326)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ナノ薬剤 / 腫瘍 / マイクロ流体デバイス

Outline of Final Research Achievements

Nanomedicines are believed to be capable of tumor-selective drug delivery, but their clinical application has not progressed. In this study, we aimed to construct a microfluidic tumor model that reflects the structure and characteristics of human tumor tissue and apply it to the evaluation of nanomedicines. Vascular endothelial cells, tumor cells, and macrophages were incorporated into the device, and the permeability and cellular uptake of nanoparticles were evaluated. Microfluidic devices suitable for microscopic observation were fabricated, and the effects of various conditions on the dynamics of nanoparticles were clarified.

Free Research Field

マイクロ・ナノ分析化学

Academic Significance and Societal Importance of the Research Achievements

本成果は、ヒトの体内でナノ薬剤がどのように動いて細胞に取り込まれるのかなど、ヒトにおけるナノ薬剤の動態予測につながるという学術的意義を有する。加えて、一般に多くの時間と費用を要する新薬開発において、動物実験を部分的に代替することでこれらの問題を解決しうるという社会的意義を有する。ヒトの腫瘍組織の構造や特性を反映したモデルで評価することで、新薬開発の成功率の向上も見込める。