2021 Fiscal Year Final Research Report
Elucidation of iron absorption mechanism in mammals by plant-derived iron chelator, the precursor of mugineic acids
| Project/Area Number |
19K05727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
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| Research Institution | Suntory Foundation for Life Sciences |
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Principal Investigator |
Murata Yoshiko 公益財団法人サントリー生命科学財団, 生物有機科学研究所・統合生体分子機能研究部, 特任研究員 (60256047)
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| Co-Investigator(Kenkyū-buntansha) |
難波 康祐 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 (50414123)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 鉄 / ニコチアナミン / 小腸 / トランスポーター / 植物性食物 / アフリカツメガエル卵母細胞 / Caco-2細胞 / Feアイソトープ |
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| Outline of Final Research Achievements |
In this research project, it was shown that the mugineic acid precursor, nicotianamine (NA) present in a plant is absorbed as an iron complex from the jejunum via the amino acid transporter proton coupled amino acid transporter 1 (PAT1). In addition, in the mouse administration experiment, the iron concentration was higher in the kidney and spleen of the mice to which the NA iron complex was administered than to the iron alone administration. The results of this study revealed that there is an absorption mechanism of iron as a new NA-iron complex in the jejunum, which is different from the existing absorption of free iron in the duodenum.
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| Free Research Field |
生化学
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| Academic Significance and Societal Importance of the Research Achievements |
植物性食物に含まれるニコチアナミンによる鉄の動態に関与する輸送体やその代謝経路を解明し、哺乳動物における新しい鉄輸送分子機構の全容を明らかにすることは学術的に意義がある。また、ヒトでも鉄欠乏症は最も一般的な栄養障害の１つであるが、同時に臓器に過剰の鉄が蓄積すると重篤な症状や合併症が生じるため、体内での適切な鉄排出も重要である。これらの成果を基盤として、鉄欠乏症および鉄過剰症の対策・治療への応用研究への展開に社会的意義がある。
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