Multi-modal analysis forcused on activated microglia in brain for developing new-generation seeds of pharmacotherapy of depression

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Kameno Yosuke 浜松医科大学, 医学部, 助教 (40537255)
• Co-Investigator(Kenkyū-buntansha): 横倉 正倫 浜松医科大学, 医学部, 助教 (00529399) ; 尾内 康臣 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978) ; 桑原 斉 浜松医科大学, 医学部, 准教授 (50456117) ; 山末 英典 浜松医科大学, 医学部, 教授 (80436493) ; 和久田 智靖 浜松医科大学, 医学部附属病院, 講師 (80444355)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: PET / うつ病 / DPA713 / DASB

Outline of Final Research Achievements

By March 2022, 16 people in the depression group and 19 people in the healthy control group were recruited. There was no significant difference in the background and WAIS-III results. On the other hand, psychological tests related to the symptoms of depression showed significant differences. General blood tests showed no significant difference between the two groups. In addition, PET examinations of depressed patients showed a significant decrease in the binding potential of DASB in the frontal and occipital lobes. MRS showed a significant decrease in GABA concentration in the medial prefrontal cortex / anterior cingulate cortex of depressed patients.
The subjects of this study are currently recruiting. Therefore, the results have not been summarized and presentations at academic conferences and publications in papers have not been possible. After recruiting a sufficient number of samples, we plan to analyze the results and publish.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

今後十分なサンプル数を確保したのちに各種解析を行い結果の解釈を行う予定である。そのため、研究成果の学術的意義や社会的意義については解析結果を踏まえて検討する予定である。