Bacterial translocation and systemic infection influenced by mucosal immunity of the gastrointestinal tract

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K08961
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: International University of Health and Welfare
• Principal Investigator: Matsumoto Tetsuya 国際医療福祉大学, 医学部, 主任教授 (10256688)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: バクテリアル・トランスロケーション / 緑膿菌 / 菌血症 / 敗血症 / プロバイオティクス / 腸管免疫 / グルタミン

Outline of Final Research Achievements

Bacterial translocation (BT) is a phenomenon in which bacteria in the intestinal tract spread to sites outside the intestinal tract via the lymphatic or blood circulatory systems, and there is a possibility that this may progress to serious infectious diseases such as bacteremia and sepsis. In this study, we investigated the effects of probiotics on bacterial factors and confirmed that there are differences in the efficacy of preventing infection even for the same bacterial species. As a factor that affects the host, we focused on glutamine, an important nutrient for the intestinal tract, and as a result of our investigation, it became clear that the survival rate of mice after induction of sepsis caused by Pseudomonas aeruginosa increased in a dose-dependent manner. These results suggest the possibility of probiotics and nutrients as factors that control BT, and their characteristics have become clear.

Free Research Field

細菌学、免疫学、感染症学

Academic Significance and Societal Importance of the Research Achievements

バクテリアル・トランスロケーションは免疫不全患者においては臨床的にも重視すべき現象であり、その有効な予防策を研究することは意義があると考えられる。今回得られた情報を基に、診療面で活用することによって抗がん剤治療や臓器移植後の患者などにおける重症感染症の予防に寄与するものと考えられる。