2021 Fiscal Year Final Research Report
Renal protective role of adiponectin and clinical significance of circulating T-cadherin concentration
Project/Area Number |
19K08980
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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Research Institution | Osaka University |
Principal Investigator |
MAEDA Norikazu 大阪大学, 医学系研究科, 寄附講座准教授 (30506308)
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Co-Investigator(Kenkyū-buntansha) |
西澤 均 大阪大学, 医学系研究科, 講師 (20379259)
喜多 俊文 大阪大学, 医学系研究科, 寄附講座講師 (10746572)
藤島 裕也 大阪大学, 医学系研究科, 助教 (10779789)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | アディポネクチン / T-カドヘリン / 慢性腎臓病 / メタボリックシンドローム / 糖尿病 |
Outline of Final Research Achievements |
We generated and analyzed a renal ischemia and reperfusion model in mice lacking adiponectin or T-cadherin. Our study clearly showed that adiponectin/T-cadherin system played a significant role in maintenance for vascular barrier function and homeostasis of vascular pericytes. Furthermore, we established ELISA system to measure soluble T-cadherin in bloodstream and demonstrated the existence of three forms of soluble T-cadherin (130-kDa, 100-kDa, and 30-kDa). Soluble T-cadherin concentrations were significantly correlated with various clinical parameters, suggesting that soluble T-cadherin is a novel biomarker.
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Free Research Field |
糖尿病・内分泌・代謝学
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、アディポネクチン/T-カドヘリンシステムは腎保護作用を有しており、慢性腎臓病や糖尿病腎症の予防・治療に応用できる可能性を示した。また、可溶性T-カドヘリンを測定することで、糖尿病や心疾患の新たなバイオマーカーとしての応用が期待される。
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