2021 Fiscal Year Final Research Report

Development of Breast Cancer Surgery Support System for MRI non mass enhancement Using Virtual Reality Technology

Research Project

PDF

Project/Area Number	19K09059
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55010:General surgery and pediatric surgery-related
Research Institution	Aichi Medical University
Principal Investigator	Nakano Shogo 愛知医科大学, 医学部, 教授 (20351108)
Co-Investigator(Kenkyū-buntansha)	藤井公人愛知医科大学, 医学部, 准教授 (00524331) 高阪絢子愛知医科大学, 医学部, 助教 (50440748) 塩見有佳子 (毛利有佳子) 愛知医科大学, 医学部, 講師 (90465576) 安藤孝人愛知医科大学, 医学部, 助教 (40634134) 井戸美来愛知医科大学, 医学部, 助教 (70740968) 伊藤由季絵愛知医科大学, 医学部, 助教 (10805469)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	Breast cancer / MRI / Non mass enhancement / RVS / 乳房温存手術
Outline of Final Research Achievements	We evaluated the usefulness of second-look US combined with ultrasound fusion technology (real-time virtual sonography: RVS) in defining the extent of breast cancer in breast-conserving surgery for breast cancer with Non-mass enhancement (NME). 6 cases were included in the study. After additional supine MRI, second-look US was performed using RVS. After tracing the contrast-enhanced area on the skin with RVS, implantable lesion identification markers were placed and surgery was performed. MRI showed a median diameter of 30.0 mm (23-36), with a distribution of 4 NME and 2 NME+mass. US showed a median diameter of 14.5mm (11-32), with a distribution of 2 NME and 4 NME+mass. All patients underwent breast-conserving surgery. The final pathological diagnosis was DCIS in 4 cases and IDC in 2. All were negative for resection margins, and there were no cases of reoperation. RVS may contribute to improved surgical outcomes in breast-conserving surgery for breast cancer with NME.
Free Research Field	乳癌画像診断
Academic Significance and Societal Importance of the Research Achievements	RVSはMRI-NMEの多くを検出できる革新的な画像診断法であり、世界に発信しうる独創的な新技術であることをfeasibility試験で検証できた。今後症例を増やしNMEの広がり診断においてRVSを用いて乳房温存手術のsurgical outcomeが改善されることが証明できれば、RVSによって必要のない乳房全摘術を回避することが可能となる。またMRIガイド下生検が必要な症例をより厳選することが可能となり、医師、患者の負担を軽減することができる。