2022 Fiscal Year Final Research Report
The regulation of immune response by anti-psychotics via oxidative stress
| Project/Area Number |
19K09387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中尾 慎一 近畿大学, 医学部, 教授 (10207714)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 樹状細胞 / Translocator protein / 接触過敏症 / IL-12 / 副刺激分子 |
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| Outline of Final Research Achievements |
Dendritic cells (DCs) play an important role in the regulation of adaptive immune responses; TSPO affects immune cells, but the effects of TSPO ligands on DCs are not known; the immunomodulatory properties of TSPO on DC-mediated immune responses were investigated.
The TSPO ligand suppressed the expression of paracrine molecules from mouse DCs. Ethifoxin-treated DCs also decreased secretion of interleukin-12, inhibited differentiation of mouse T cells to Th1 in mixed cell culture with T cells, and inhibited contact hypersensitivity responses in TSPO ligand-treated DCs. This suggests the possibility of controlling inflammatory diseases by intervening in TSPO signaling.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
申請者らは、Translocator protein (TSPO)を介したベンゾジアゼピン系薬物によるシグナル伝達が、単一の細胞に対する作用を超えて動物個体レベルの免疫系に影響することを今までの研究で示してきた。本研究では実際に臨床的に用いられるTSPOに対する低分子リガンドを用いてこの経路に介入することによる免疫疾患モデルを抑制制御する可能性を示した。この結果はこのアプローチが実現可能な治療の選択肢になる可能性を示唆している
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