Comprehensive analysis of cerebral metabolism and cerebrospinal fluid changes in subarachnoid hemorrhage patients

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09507
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kobe University
• Principal Investigator: Uozumi Yoichi 神戸大学, 医学研究科, 助教 (50815446)
• Co-Investigator(Kenkyū-buntansha): 甲村 英二 神戸大学, 医学研究科, 名誉教授 (30225388) ; 谷口 理章 神戸大学, 医学研究科, 准教授 (60346195) ; 中井 友昭 神戸大学, 医学研究科, 助教 (60596089) ; 木村 英仁 神戸大学, 医学部附属病院, 講師 (90514753)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: くも膜下出血 / 脳血管攣縮 / ストレス関連ホルモン

Outline of Final Research Achievements

In patients with subarachnoid hemorrhage, about 20% develop a phenomenon called symptomatic vasospasm, which causes sequelae such as paralysis, impaired consciousness, aphasia and so on. Its onset is unpredictable. The purpose of this study is to predict this symptomatic vasospasm. We investigated accumulated patients' blood sampling data, and newly showed that arginine vasopressin (AVP), adrenocorticotropic hormone (ACTH), and serum cortisol on the onset of subarachnoid hemorrhage are significantly higher in patients with symptomatic vasospasm than in patients without symptomatic vasospasm. It was suggested that these data could be used to predict cerebral vasospasm and be helpful for future patients with subarachnoid hemorrhage to get better outcome.

Free Research Field

くも膜下出血

Academic Significance and Societal Importance of the Research Achievements

本研究結果を将来のくも膜下出血患者の治療に生かすことができれば、どのくも膜下出血患者がより脳血管攣縮を生じやすいかが予測できるようになる。さらにくも膜下出血患者治療中に生じる脳血管攣縮の予防が可能となる可能性が示された。