Pathophysiology of periodontitis progression by IL-1 and geriatric impaired testosterone in diabetic patients

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: The University of Tokushima
• Principal Investigator: NARUISHI Koji 徳島大学, 病院, 講師 (00346446)
• Co-Investigator(Kenkyū-buntansha): 木戸 淳一 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 (10195315) ; 二宮 雅美 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (10291494)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 糖尿病関連歯周炎

Outline of Final Research Achievements

Testosteron did not induce IL-1b, IL-6 and sgp130 in human gingival fibroblasts (HGFs). MMP-1 expression was significantly induced in HGFs treated without testosterone, and the expression was gradually suppressed in HGFs treated with dose-dependent Testosterone. Interestingly, MMP-1 expression was significantly induced in HGFs cultured with high glucose conditions treated without testosterone.
These results showed that periodontitis may be more severed in elderly diabetic patients, in case of without bacterial infection.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

老齢性テストステロン低下が歯周組織のMMP-1産生を誘導することは，言い換えると，高齢になると「細菌感染」がなくても歯周組織のコラーゲン線維が破壊されるという新たな老年性歯周炎の病態機序を説明し得るエビデンスとなった。さらに重要なことに，この条件に加えて高グルコース条件下で培養した細胞は，より一層のMMP-1産生を誘導したことから，糖尿病関連歯周炎は高齢者においてさらに重症化する可能性が示唆された。