Basic study of the bioactive substances of a skin of citrus fruits for periodontal disease treatment

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: The University of Tokushima
• Principal Investigator: HOSOKAWA Yoshitaka 徳島大学, 病院, 講師 (90346601)
• Co-Investigator(Kenkyū-buntansha): 中西 正 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 (00217770) ; 細川 育子 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (50707908)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯周炎 / 柑橘類果皮 / 生理活性物質 / 抗炎症作用

Outline of Final Research Achievements

Periodontitis is a chronic inflammatory disease caused by periodontal pathogen, and it is reported that excessive immune response participates in periodontium destruction. Thus, it is thought that it is important to find new candidates of the bioactive substance which have anti-inflammatory effects. I focus on nobiletin and sudachitin which were the bioactive substance included in the skin of citrus fruits in this study and I examined the anti-inflammatory effects of nobiletin and sudachitin in vitro study. As a result, I found that nobiletin and sudachitin inhibited the inflammatory mediator productions such as chemokines in human periodontal ligament cells. Thus, this results suggested that the local application of nobiletin and sudachitin might decrease the inflammatory mediator expression in periodontal lesion.

Free Research Field

歯周治療学分野

Academic Significance and Societal Importance of the Research Achievements

歯周炎はその進行により歯を喪失し国民のQOLの低下に関与する慢性炎症性疾患であり、糖尿病や心筋梗塞など他の疾患の病態への関与も報告されている。ゆえに歯周炎の進行や発症を抑える可能性がある抗炎症作用がある生理活性物質の候補を増やす事は重要であると考えられる。本研究では柑橘類果皮に含まれる生理活性物質であるノビレチンとスダチチンが歯周組織構成細胞に対して抗炎症作用がある事を明らかとした。普段廃棄される果皮に含まれる生理活性物質でもありSDGsの観点からも環境に優しい歯周炎に使用できる生理活性物質候補であると考えている。