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2021 Fiscal Year Final Research Report

Establishment of genetic management methods for endangered animals by genome-wide and epigenome analysis for in situ conservation.

Research Project

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Project/Area Number 19K15861
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 39060:Conservation of biological resources-related
Research InstitutionKyoto City Zoo

Principal Investigator

Ito Hideyuki  京都市動物園, 生き物・学び・研究センター, 研究教育係長(獣医師) (10779648)

Project Period (FY) 2019-04-01 – 2022-03-31
Keywords集団遺伝 / 絶滅危惧種 / ツシマヤマネコ / 年齢推定 / 全ゲノム解析 / エピゲノム解析
Outline of Final Research Achievements

Genetic information is important for the conservation of endangered animals because various findings are necessary for the conservation of endangered animals. In this project, reference genomes of the Tsushima leopard cat, bush dog, Humboldt penguin and Grevy's zebra, which are important endangered species, were produced and made public.
For the Tsushima leopard cat, we evaluated genetic diversity using whole genome, microsatellite markers, and Gras-Di analysis, a genome-wide analysis, and compared the Tsushima leopard cat with other Bengal leopard cat populations, and found that the Tsushima leopard cat has lower genetic diversity than other populations. In chimpanzees and Japanese macaques, we created an age estimation method using DNA methylation, an acquired employment of DNA, as an indicator.

Free Research Field

保全遺伝学、獣医学

Academic Significance and Societal Importance of the Research Achievements

現在、多くの種が絶滅の危機にあり、これらの種の保全は重要な課題である。希少動物の保全には様々な知見が必要であり、遺伝情報の把握も重要である。
本調査では絶滅危惧種4種(ツシマヤマネコ、ヤブイヌ、グレビーシマウマ、フンボルトペンギン)の全ゲノム情報を取得し、リファレンスゲノムを作製・公開した。また、複数個体の全ゲノム情報を取得し、遺伝子の多様性に関する情報を取得した。全ゲノムから得られた遺伝的情報は、これまでの少数のDNAマーカーから得られた情報よりも、有用性が高く、遺伝的多様性の把握や疾患に関連する遺伝子の特定など、今後の遺伝管理に有益な情報になると考えられる。

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Published: 2023-01-30  

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