2019 Fiscal Year Research-status Report
分子異常をエビデンスとした高リスク乳頭がんの形態学的形質分析
| Project/Area Number |
19K16587
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| Research Institution | Nagasaki University |
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Principal Investigator |
ムサジャノワ ジャンナ 長崎大学, 原爆後障害医療研究所, 助教 (30770432)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | PTC / FFPE |
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| Outline of Annual Research Achievements |
We have already collected 160 cases of FFPE PTC tissue of Japanese patients and 250 cases of Kazakh patients. All cases were evaluated for BRAF mutation, TERT promoter C228T and C250T mutations, and Ki-67 labeling index. Now detailed analysis of histology and collection of samples are continuing. For instance, BRAFV600E is reported to find in 82% of Japan and 67% of Kazakh population, and TERT promoter in 25% of Japan and 5% of Kazakh population. Associations between BRAFV600E mutation with TERT promoter, and Ki-67 LI, and clinicopathologic factors will be presented to further.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We have already collected 160 cases of FFPE PTC tissue of Japanese patients and 250 cases of Kazakh patients. All cases were evaluated for BRAF mutation, TERT promoter C228T and C250T mutations, and Ki-67 labeling index. Now detailed analysis of histology and collection of samples are continuing. For instance, BRAFV600E is reported to find in 82% of Japan and 67% of Kazakh population, and TERT promoter in 25% of Japan and 5% of Kazakh population.
Associations between BRAFV600E mutation with TERT promoter, and Ki-67 LI, and clinicopathologic factors will be presented to further.
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| Strategy for Future Research Activity |
We continuing collecting of cases of FFPE PTC tissue of Japanese patients and Kazakh patients. And planning to evaluate for BRAF mutation, TERT promoter C228T and C250T mutations, and Ki-67 labeling index. Now detailed analysis of histology and collection of samples are continuing. And last statistical analysis of associations between BRAFV600E mutation with TERT promoter, and Ki-67 LI, and clinicopathologic factors will be performed.
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