Role of ROS sensitive TRP channels in visceral pain associated with IBD

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16935
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51030:Pathophysiologic neuroscience-related
• Research Institution: Hyogo University of Health Sciences
• Principal Investigator: Kogure Yoko 兵庫医療大学, 薬学部, 助教 (60548684)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 内臓痛 / TRP受容体 / 大腸炎 / 活性酸素

Outline of Final Research Achievements

Inflammatory bowel disease (IBD) chronically persistent abdominal pain and medicines which control the pain are not developed. Daikenchuto is herbal medicine used for abdominal pain, bloating sensation or constipation. We revealed that Daikenchuto effects on eosinophils and also beneficial for the pain associated with IBD. On the other hand, existing medicines 5-aminosalicylic acid (5-ASA) effects on eosinophils but not suppressed abdominal pain. TRPC5 and TRPV3 receptors are sensor for physical and chemical stimulus and it is reported that these receptors are activated by reactive oxygen spieces increased in IBD. We suggested that TRPC5 and TRPV3 receptors are involved in the onset of abdominal pain accompanied with IBD.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究より、メサラジンと大建中湯の炎症性腸疾患に対する作用は部分的に異なっていることが明らかとなった。大建中湯とメサラジンを併用することで、炎症性腸疾患に伴う腹痛症状の緩和や症状悪化の予防に効果を発揮できると期待される。また、TRPC5やTRPV3受容体が炎症性腸疾患に関わることを示唆したのは本研究が初めてである。今後の腹痛治療薬の開発においてこれらが新しいターゲットとなり、腹痛治療の進展に貢献できるであろう。