Development of algorithm to predict the repair kinetics of cluster DNA lesions induced by carbon ions using super resolution microscopy

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17162
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Gunma University
• Principal Investigator: Oike Takahiro 群馬大学, 医学部附属病院, 講師 (10643471)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 炭素イオン線

Outline of Final Research Achievements

In the first fiscal year, we obtained high-precision 3D data of double-strand breaks induced by carbon-ions of various LETs under normoxic conditions. However, due to the subsequent COVID-19 pandemic, it became practically impossible to carry out further experiments (see the annual performance reports for details). Thus, we changed the research plan to focus on publishing all the data obtained up until that time, including secondary findings, in order to contribute to scientific community. As a result, we published three papers in English peer-reviewed journals and made nine presentations at scientific meetings.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

申請者の知る限り正常酸素環境下で多様なLETの炭素イオン線によって誘導される二本鎖切断の高精度3次元データの取得は世界初である。今後はこれを論文として発表する。発表されれば同データはLETの最適化による炭素イオン線がん治療のさらなる個別最適化に資する重要な生物学的基盤情報となると考えられる。