2020 Fiscal Year Final Research Report
Analysis of anti-tumor immunity in steatohepatitis-related hepatocellular carcinoma
| Project/Area Number |
19K17455
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 脂肪肝炎関連肝癌 / 樹状細胞 |
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| Outline of Final Research Achievements |
In this study, we analyzed the peripheral blood and hepatocellular carcinoma tissue-infiltrating immune cells of patients with steatohepatitis-related hepatocellular carcinoma to characterize the immune cells involved in liver fibrosis progression and hepatocarcinogenesis. Compared with virus-related hepatocellular carcinoma, steatohepatitis-related hepatocellular carcinoma showed significant differences in immune cell profiles, including dendritic cells, which tended to be associated with treatment response and prognosis.
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| Free Research Field |
消化器内科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では脂肪肝から肝硬変，肝癌に至るまでの進展を一種の免疫異常として捉え，宿主免疫応答の中心を担い抗原提示細胞である樹状細胞に着目し，臨床データと統合することで本疾患に特徴的な免疫細胞の基盤情報を明らかにした．本研究の結果は，脂肪肝炎を背景とする肝癌のみならず，今後他臓器癌における免疫学的側面を研究し，新規免疫治療を確立するための重要な基盤情報になると考えている．
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