Comprehensive lipidomics of skin lipid profiles in the development of dermatitis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17816
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Keio University
• Principal Investigator: Naganuma Tatsuro 慶應義塾大学, 薬学部(芝共立), 助教 (60779619)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: リピドミクス / 脂質 / 皮膚炎 / LC-MS/MS

Outline of Final Research Achievements

Various lipids are indispensable for the maintenance of skin homeostasis, and disregulated lipid metabolism can cause disease onset of dermatitis such as atopic dermatitis. To clarify the disease pathogenesis of dermatitis, it’s important to capture the comprehensive lipidome profile in the course of disease onset and progression. We performed LC-MS/MS based comprehensive lipidomics in mouse model of atopic dermatitis. As a results, we found unique alterations of lipid metabolism involved in disease onset and progression and underlying mechanisms for the disuregulation of lipid balances.

Free Research Field

脂質生化学

Academic Significance and Societal Importance of the Research Achievements

これまでに様々な皮膚疾患において脂質組成異常が認められていたが，疾患発症後の解析であったため多くの脂質分子に異常が生じており，病態を引き起こす正体は明らかではなかった。本研究では，症状が出る前の段階で生じる脂質代謝異常を特定し，皮膚疾患の発症および悪化に関わる脂質代謝異常の一つを見出すことに成功した。また，脂質組成異常を生じる原因となる酵素反応を示唆し，皮膚炎の治療に有効な新規標的候補を見出したと言える。