Association of KIR genotype profile on the development of EBV-related iatrogenic immunodeficiency-associated lymphoproliferative disorders

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17825
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kanazawa University
• Principal Investigator: Iwaki Noriko 金沢大学, 医学系, 助教 (10825706)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: EBV関連リンパ増殖性疾患 / KIR遺伝子プロフィル

Outline of Final Research Achievements

To identify the association between KIR gene polymorphisms and susceptibility to EBV-LPD (EB virus-associated lymphoproliferative disorder), we determined EBV copy numbers in the whole blood of patients suspected of having EBV-LPD using quantitative real-time PCR, and determined the KIR gene profile of these patients as well as those who develop non-EBV associated lymphoma and healthy individuals using PCR with specific primers. In patients with EBV-LPD, the frequencies of KIR2DS1, 2DS5 and 2DL5 were significantly lower than those in healthy individuals and non-EBV associated lymphoma. The result suggests that the KIR gene repertoire may be associated with susceptibility to EBV-LPD.

Free Research Field

悪性腫瘍

Academic Significance and Societal Importance of the Research Achievements

KIR 遺伝子プロフィルがEBV-LPDの発症に影響する可能性が示唆されたことで、免疫抑制療法中の患者において、よりEBV-LPDを発症しやすい患者群の特定につながる可能性がある。また、EBV再活性を来した患者において、治療方針の改善につながる可能性がある。