The variety of colorectal cancer by VEGF-R: Elucidation of resistance mechanisms to anti-angiogenic therapies

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18135
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Tokyo Kasei University
• Principal Investigator: Tomida Chisato 東京家政大学, 家政学部, 期限付助教 (60827385)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: VEGF受容体

Outline of Final Research Achievements

The purpose of this study is to elucidate the role of VEGF receptor in colorectal cancer cells. I investigated which of the VEGF receptors expressed by colorectal cancer cells enhances migration ability. As a result, As a result, it was clarified that the migration ability is enhanced by adding a specific inhibitor for VEGF receptor 1 to colorectal cancer cells. Inhibition of VEGF receptor 1 increased revels of phosphor c-Met. It was suggested that inhibition of VEGF signal from VEGF receptor 1 may play an important role in the acquisition of migration ability under VEGF receptor inhibitor.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

VEGF(血管内皮増殖因子)やVEGF受容体を標的とした血管新生阻害治療は固形がんにおける化学療法において中心的な役割を果たしている。しかしながら、その効果は一時的であり、多臓器への転移など治療抵抗性を獲得することが臨床現場で問題となっている。本研究は、がん細胞に発現するVEGF受容体と血管新生阻害薬の関係に着目し、がんが治療抵抗性を獲得する仕組みを解明することを目的としている。得られた知見を応用し、転移を根本的に阻止できる新たな治療方法の開発を目指す。