2022 Fiscal Year Final Research Report
Analysis of NOTCH1 Signal in Esophageal Cancer Invasion
Project/Area Number |
19K18156
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Nagoya City University |
Principal Investigator |
Okubo Tomotaka 名古屋市立大学, 医薬学総合研究院(医学), 助教 (70770238)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 食道癌 / NOTCH1 |
Outline of Final Research Achievements |
Clinical specimens of esophageal cancer were used to investigate whether there is a prognostic difference in the expression of NOTCH1. no clear causal relationship between NICD expression and prognosis was found. Esophageal cancer cell lines were used for forced expression or suppression of NOTCH1. WST-1 assay, Ki67, etc. were examined for proliferative potential, and Invasion assay and E-cadherin, etc. were examined for invasive potential, but no significant results were obtained.
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Free Research Field |
消化器外科
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Academic Significance and Societal Importance of the Research Achievements |
本研究では食道癌におけるNOTCH1の意義の解明にはつながらなかった。
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