2021 Fiscal Year Final Research Report
Establishment of head and neck cancer model animal and investigation of molecular mechanism about therapeutic effect of the oncolytic virus HF10
| Project/Area Number |
19K18778
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 56050:Otorhinolaryngology-related
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Takano Gaku 名古屋市立大学, 医薬学総合研究院(医学), 講師 (00812744)
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | 腫瘍溶解ウイルス / 口腔癌マウスモデル |
|---|
| Outline of Final Research Achievements |
We have successfully established a new oral carcinoma cell line, NMOC1, that can be used to form tongue tumors in a mouse model. We have also demonstrated the oncolytic activity of HF10 in tongue tumor models. HF10 replicated in the tumor cells and killed oral carcinoma cells in vitro and in vivo. Immunohistochemical staining showed that HF10 induced infiltration of tumor infiltrating lymphocyte in the tumor mass, implying increased anti-tumor immunity.
|
| Free Research Field |
耳鼻咽喉科学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究で樹立した舌癌マウスモデルは安定して形成され、また正常な免疫能を持つ独自の口腔癌モデルであり、今後の頭頸部癌基礎研究に応用が可能と考えられた。また口腔癌マウスモデルにおけるHF10の治療効果を評価したところ、良好な抗腫瘍効果を認め、HF10が口腔癌の治療に有望な薬剤であることが示された。これらより本研究が頭頸部癌におけるウイルス療法の臨床応用への基盤になると考えられた。
|
