2021 Fiscal Year Final Research Report
Understanding the morbid state of the frailty from the intestinal ecosystem and investigation of biomarkers for early diagnosis
| Project/Area Number |
19K19128
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 要介護高齢者 / フレイル / 口腔内細菌叢 / 腸内エコシステム / 16S rRNA解析 |
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| Outline of Final Research Achievements |
When older people require nursing care, frailty including oral frailty might be one of the previous step parameter but these morbid states were not enough revealed. On the other hand, relationship between the modulation of intestinal ecosystem and the frailty onset has been reported. This prospective cohort study aimed to investigate the relationship between frailty onset between human enterobacteria. Totally, 22 older people who required nursing care at nursing home were enrolled in this study. Clinical experiments and excrement sample collection were performed. During the observation period, 16 participants were dead, and average survival time of analyzed subjects were 806.6 +/- 562.8 days. As a result of microbiota analysis, 55 kinds of families were identified.
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| Free Research Field |
補綴系歯学関連
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| Academic Significance and Societal Importance of the Research Achievements |
フレイルは，身体的・精神心理的・社会的背景が複雑に絡み合い関わって発症する疾患であるため，治療法のみならず診断基準についてもコンセンサスが得られていないのが現状である．本研究成果は，フレイルを腸内エコシステムの変調と捉え，腸内細菌叢の観点からその発症の原因を解き明かそうとした点で，学術的独自性が高い．また，本研究の発展は，治療法の開発に繋がるのみならず，診断基準や重症度分類をも変える可能性を秘めており，フレイルの新たな概念を提唱するものとなる．世界一の長寿国日本が抱える医療界最大の課題であるフレイルの理解は，医療界に革新をもたらすことに疑いの余地がない，創造的かつ革新的な研究である．
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