Effects of carbohydrate and fatty acid intakes and genetic polymorphisms on the development of dyslipidemia

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21481
• Project/Area Number (Other): 18H06402 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: Aichi Medical University
• Principal Investigator: Sasakabe Tae 愛知医科大学, 医学部, 講師 (90828774)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 脂質異常症 / 炭水化物 / 脂肪酸 / 遺伝子多型

Outline of Final Research Achievements

The aim of this study was to examine the influence of genetic factors in the associations between carbohydrate and fatty acid intakes and dyslipidemia. For participants in the Shizuoka and Daiko areas of the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study), we identified three genetic polymorphisms that have been suggested to be related to the regulation of lipid metabolism and others, and examined the influence of the associations between carbohydrate and fatty acid (saturated, monounsaturated, and polyunsaturated fatty acids) intakes and the development of dyslipidemia. We found no modification by the genetic polymorphisms examined in this study on the associations between carbohydrate and fatty acid intakes and dyslipidemia.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

日本人一般集団において炭水化物や脂肪酸摂取と脂質異常症の関連への遺伝的素因による影響の違いを検討することは、個人差を考慮した脂質異常症予防に役立つと考えられる。本研究では対象とした遺伝子多型による修飾を示すことができなかったが、今後、他の栄養素や遺伝子多型による検討が期待される。