2020 Fiscal Year Final Research Report
Functional analysis of Aire expressing dendritic cell with AGF mice.
Project/Area Number |
19K23846
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0803:Pathology, infection/immunology, and related fields
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Research Institution | The University of Tokushima |
Principal Investigator |
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Project Period (FY) |
2019-08-30 – 2021-03-31
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Keywords | Aire / 樹状細胞 / カンジダ・アルビカンス |
Outline of Final Research Achievements |
Though APECED patients show autoimmune and candida albicans infection, there are still many unclear points about the cause. In this study, we hypothesized that AIRE expressed in dendritic cells plays an important role in the control of oral candidiasis. Therefore, we analyzed the immune system of AIRE expressing dendritic cell against candida albicans. We found that AIRE expressing dendritic cell showed lower response against candida albicans in the AIRE deficient condition. In one hand, AIRE expressing dendritic cell showed no expression of tissue-restricted antigens expressed in medullary thymic epithelial cell. There results indicate that AIRE in dendritic cell has different function to AIRE in medullary thymic epithelial cell.
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Free Research Field |
免疫学
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Academic Significance and Societal Importance of the Research Achievements |
胸腺髄質上皮細胞で発現するAIREは、免疫システムの根幹である自己・非自己の教育を行う重要な遺伝子であり、その機能の全容解明が求められている。本研究において樹状細胞におけるAIREの機能を示したことは、AIREに関する知見の拡充に繋がると考えられる。更に、AIRE欠損症を始め多くの免疫疾患では、カンジダを始めとする常在細菌への感染が認められるが、AIRE欠損症における口腔カンジダに対する新たな治療に繋がる可能性がある。
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