2020 Fiscal Year Final Research Report
The deficiency of indoleamine 2,3-dioxgenase 2 enhances liver regeneration in mouse after partial hepatectomy
Project/Area Number |
19K23873
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Multi-year Fund |
Review Section |
0803:Pathology, infection/immunology, and related fields
|
Research Institution | Fujita Health University |
Principal Investigator |
ando tatsuya 藤田医科大学, 共同利用研究設備サポートセンター, ポスト・ドクター (50796068)
|
Project Period (FY) |
2019-08-30 – 2021-03-31
|
Keywords | 肝再生 / 炎症 / トリプトファン代謝酵素 |
Outline of Final Research Achievements |
After loss of hepatic cells by hepatectomy for liver transplantation or acute liver damage, liver regeneration starts immediately and hepatic failure is prevented. In this study, we examined the roles of Ido2 in the liver regeneration using Ido2 gene deficient mice. The liver-body weight ratio significantly increased in Ido2-KO mice compared to that in WT mice after PHx. The number of Ki-67 and PCNA positive cells per field significantly increased in Ido2-KO mice compared to that in WT mice. The mRNA expression of IL-6 and TNF-α in the intrahepatic MNC of Ido2-KO mice significantly increased compared to that of WT mice. NF-kB (p65) intranuclear transport facilitated in Ido2-KO mice compared to WT mice after LPS stimulation. In conclusion, the results in the present study suggested that Ido2 deficiency enhanced NF-κB pathway and augmented inflammatory cytokine production in the intrahepatic MNC after PHx.
|
Free Research Field |
免疫学
|
Academic Significance and Societal Importance of the Research Achievements |
本研究により、肝臓にて発現するIDO2の役割を肝再生の観点から明らかにしたことで、肝再生が必要な急性疾患、移植後の予後の安定化に寄与する可能性が示唆される。
|