Elucidation of immune response suppression mechanism of transcription factor ASCL1 in lung cancer and its clinical application

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23981
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0903:Organ-based internal medicine and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Miyashita Naoya 東京大学, 医学部附属病院, 助教 (50843041)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 肺癌 / 腫瘍免疫 / トランスクリプトーム解析

Outline of Final Research Achievements

We have studied the effects of the transcription factor ASCL1 on the tumor immune system of lung cancer using techniques such as cell experiments, mouse experiments, and existing public data analysis.
As a result, we clarified a part of the mechanism by which the expression level of specific cytokines and their receptors is low in lung adenocarcinoma expressing ASCL1 and the tumor immunological mechanism is suppressed.

Free Research Field

肺癌

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、肺癌においては特定のマスター転写因子の発現によってその腫瘍免疫機構に大きな差があることが明らかになった。現在の臨床の現場では免疫療法が盛んにおこなわれるようになっており、本研究の成果により、将来的には特定の遺伝子の検査により免疫療法の効果予測や適応の判定ができるようになる可能性があると考える。