The novel effect of hydrogen for IFALD in rat model

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24017
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0905:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Kagoshima University
• Principal Investigator: Ikee Takamasa 鹿児島大学, 医歯学総合研究科, 客員研究員 (90363613)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 短腸症候群 / ＩＦＡＬＤ / 抗酸化物質 / 水素水

Outline of Final Research Achievements

Short bowel syndrome (SBS) patients require postoperative total parenteral nutrition (TPN), but intestinal failure associated liver damage (IFALD) is a life threatening complication of TPN. It has been reported that the cause of IFALD is tissue damage caused by free radicals, and hydrogen, which is an antioxidant, was administered to SBS model rats to examine its preventive and therapeutic effect on IFALD. Hydrogen was decided to be administered intravenously using a hydrogen-encapsulated infusion preparation that dissolves high-concentration hydrogen. However, the half-life of the dissolved hydrogen is 3 hours or less, so the method of administration the dissolved hydrogen concentration to the model rat while stabilizing the hydrogen concentration has not been established with the existing equipment. Further examination of the administration method is required.

Free Research Field

ＩＦＡＬＤ

Academic Significance and Societal Importance of the Research Achievements

新しい抗酸化物質によるIFALDの予防的効果が明らかになれば、難渋するIFALD診療における画期的な予防・治療法の開発に繋がる。水素は安価で入手も容易な物質であり、静脈内への投与方法を含め、抗酸化物質としての使用方法が確立されれば、小児のＳＢＳ患児のみならず、成人のＳＢＳ患者やＩＦＡＬＤと同様の肝障害に対する治療に応用できる。本研究の対象となる患者数は潜在的に非常に多いと考えられる。