2020 Fiscal Year Final Research Report
Development of a method for promoting biological rotator cuff repair using peritoneal transplantation
Project/Area Number |
19K24050
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0906:Surgery related to the biological and sensory functions and related fields
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Research Institution | Osaka City University |
Principal Investigator |
Ichikawa Koichi 大阪市立大学, 大学院医学研究科, 登録医 (20780076)
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Project Period (FY) |
2019-08-30 – 2021-03-31
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Keywords | 腱骨連結部 / 骨膜移植 / PRF / 生物学的修復 |
Outline of Final Research Achievements |
Rotator cuff tear is one of the major factor in the dysfunction of the elderly, and establishing an optimal treatment method is directly linked to the extension of healthy life expectancy. The purpose of this study is to develop a method for promoting biological rotator cuff repair using peritoneal transplantation and PRF. In histological evaluation, good repair of the tendon bone connection was seen in the peritoneum with PRF combination group compared with the control group. In the histological scoring of the tendon bone repair, the score was significantly higher in the peritoneum with PRF combination group compared to the control group and the PRF alone group.
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Free Research Field |
整形外科学
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Academic Significance and Societal Importance of the Research Achievements |
腱骨連結部の修復術時に骨膜移植とPRFを併用した報告は、基礎及び臨床の両方において認めない。修復部の力学的強度の増強と、移植骨膜からの軟骨再生及び成長因子を含んだPRFの効果によって、fibrocartilageを含んだenthesisに特徴的な4層構造の再構築が可能になれば、より優れた術式の開発に繋がり、臨床応用に直結すると期待される。今後益々増えることが予想される整形外科の変性疾患の治療に対して大きく貢献する可能性がある。
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