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2020 Fiscal Year Final Research Report

Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone

Research Project

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Project/Area Number 19K24084
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0907:Oral science and related fields
Research InstitutionTohoku University

Principal Investigator

Shobara Kenta  東北大学, 大学病院, 医員 (50845906)

Project Period (FY) 2019-08-30 – 2021-03-31
Keywordsインプラント / オッセオインテグレーション
Outline of Final Research Achievements

The aim of this study is examine the effects of low-intensity pulsed ultrasound (LIPUS) and low-magnitude high-frequency (LMHF) loading (both alone and in combination) on peri-implant osteogenesis in rat tibiae. The ultimate goal is the clinical application of these two physical stimulation methods to promote osseointegration and peri-implant osteogenesis in patients with poor bone quality and bone mass.
The results of this study suggest that the combined use of LIPUS and LMHF loading promotes osteogenic activity in peri-implant bone.

Free Research Field

歯学

Academic Significance and Societal Importance of the Research Achievements

今日の患者層の高齢化により骨質・量が不十分な患者,また骨粗鬆症や糖尿病などの患者では,インプラント治療の成功率が著しく低下する.このような骨質・量や骨治癒の低下した患者に対し,薬物療法(副作用や高額などの問題)に代わる治療法が求められている.本研究は,医科,特に整形外科領域で注目されているLIPUSや LMHF loading等の物理的手法の骨形成活性効果をオッセオインテグレーションおよび周囲骨の治癒に応用しようとするものであり,この手法は薬物療法に代わる補助療法や骨造成後の骨治癒促進療法など,インプラント治療のさらなる発展へと繋がり得るものである.

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Published: 2022-01-27  

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