Development of the new safe and simple technique to promote healing of the peri-implant tissues

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K24149
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Imai Mikio 九州大学, 大学病院, 助教 (40848016)
• Project Period (FY): 2019-08-30 – 2023-03-31
• Keywords: ベニジピン

Outline of Final Research Achievements

Alveolar bone volume always decreases to a certain extent after tooth extraction, causing difficulties in the fields of prosthetic dentistry and dental implantology. In this study, we focused on benidipine, a drug for hypertension that has been reported to promote bone formation, and investigated its effect on healing of the surrounding tissue after implant placement. Using a rat model with the placement of an experimental implant, we administered PLGA microcarriers containing benidipine simultaneously with the implant　placement and confirmed that the bone-implant contact ratio was improved. This suggests that benidipine may promote peri-implant healing.

Free Research Field

歯学

Academic Significance and Societal Importance of the Research Achievements

欠損した歯を補う治療方法としてインプラント治療が選択されているが、治療に必要な骨量が不足している場合がほとんどである。骨量が不足した場合には骨造成を行うが、手技が煩雑であり、患者の負担も大きいなどの欠点がある。本研究では、薬剤を抜歯窩近傍に単回投与するだけで骨形成を促進させることに成功した。このことは、インプラント治療の簡便化へと繋がる知見であるといえる。