2020 Fiscal Year Final Research Report
A three-dimensional distribution of sensory modality in the rat trigeminal ganglion
Project/Area Number |
19K24151
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0907:Oral science and related fields
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Research Institution | Kagoshima University |
Principal Investigator |
Ryozo Sendo 鹿児島大学, 鹿児島大学病院, 助教 (30852107)
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Project Period (FY) |
2019-08-30 – 2021-03-31
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Keywords | 三叉神経節 / 感覚モダリティ / 3次元分布 |
Outline of Final Research Achievements |
Since it is expected that nerve cell bodies responsible for pain sensation in distant sites related to ectopic pain will be close to each other, the aim of this study is to clarify a three-dimensional distribution pattern of sensory modalities in the rat trigeminal ganglion. As a research method, we applied a method that combines tissue clearing technology, retrograde tracer, and immunohistochemical staining. This study provided us with the morphological basis needed to conduct basic research on rat trigeminal ganglion interactions. As future developments, it is expected that the ectopic pain mechanism will be elucidated from the spatial aspect, and that it will be applied to new treatment methods for neuropathic pain for peripheral nerves.
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Free Research Field |
解剖生理学
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Academic Significance and Societal Importance of the Research Achievements |
得られた結果より、今後の臨床研究やトランスレーショナルな研究への発展が期待される。展開としては、異所性疼痛メカニズムの空間的側面からの解明、延いては末梢神経に対する神経障害性疼痛の新たな治療法への応用が期待される。
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